The Efficacy of TCD Following by TP Maintenance Therapy in Newly Diagnosed WM

Enrolled patients will accept maximum 8 cycles of thalidomide plus cyclophosphamide and dexamethasone. if a partial remission response or better is achieved, thalidomide plus prednisone maintenance therapy will be given for no more than two years.

Inclusion criteria

• Aged >=18 years
• diagnosed with WM
• Untreated or mild treated without standard regimens,especially untreated with rituximab and/or bortezomib
• symptom patients
• with life-expectancy more than 3 months.

Exclusion criteria

• diagnosed with other malignancies outside B-NHL within one year(including active centre neural system lymphoma)
• Transformed lymphoma
• liver or renal function lesion unrelated to lymphoma
• serious complications such as uncontrolled diabetes,gastric ulcer or other serious angiocardiopathy determined by the physician
• HIV positive or active HBV infection or other uncontrolled systematic infection
• clinical central nervous dysfunction
• serious surgery within 30 days
• pregnancy or baby nursing period or un-contracepted child-bearing period woman;
• allergy to the trail drugs.