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Completed

NCT Number: NCT02796417

The Efficacy of REHACOP Program in Schizophrenia

This study examined the efficacy of an integrative cognitive remediation program (REHACOP) to improve cognition, social cognition, clinical symptoms and functional outcome in patients with schizophrenia.

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Deusto

Bilbao, Biskai, 48007, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnostic criteria for Schizophrenia according to American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)

Exclusion criteria

  • evidence of alcohol or drug abuse in the last 30 days
  • previous history of significant lack of consciousness
  • mental retardation
  • relevant neurological or medical condition

Treatment and study plan

REHACOP

Behavioral

REHACOP group consists of 90-minute-long sessions 3 days per week. Specifically, REHACOP group remediation consisted of: Attention unit (4 weeks) training sustained, selective, alternant and divided attention; Memory unit (3 weeks) focusing on visual and verbal learning, recall and recognizing memory; Language unit (3 weeks) including grammar, syntax, vocabulary, verbal fluency, verbal comprehension, abstract language; Executive functions unit (2 weeks) training cognitive planning, proverbs, analogies; and Social cognition unit (1 week) exercising theory of mind, social reasoning and moral dilemmas

Occupational activities

Behavioral

Occupational group activities conducted included drawing, gardening, reading the daily news and constructing using different materials (such as paper or wood).

Primary outcomes

  1. Change in functional competence after receiving cognitive remediation

    Time frame: 4 months

    functional competence was measured with San Diego UCSD Performance-Based Skills Assessment- UPSA

  2. Change in global functioning after receiving cognitive remediation

    Time frame: 4 months

    global functioning measured with Global Assessment of Functioning (GAF)

  3. change in verbal memory after receiving cognitive remediation

    Time frame: 4 months

    Verbal memory performance was assessed with the Hopkins Verbal Learning Test-HVLT (Brandt and Benedict 2001)

  4. change in processing speed after receiving cognitive remediation

    Time frame: 4 months

    Processing speed was assessed with Digit Symbol subtest from Wechsler Adult Intelligence Scale-III (Wechsler 1997)

Secondary outcomes

  1. change in emotion perception after receiving cognitive remediation

    Time frame: 4 months

    emotion perception was assessed with Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT)

  2. change in clinical symptoms after receiving cognitive remediation

    Time frame: 4 months

    Clinical symptoms was measured with Positive and Negative Syndrome Scale (PANSS)

  3. change in social perception after receiving cognitive remediation

    Time frame: 4 months

    Social perception was assessed with the Social Featuring Recognition Test (SFRT)

  4. change in theory of mind after receiving cognitive remediation

    Time frame: 4 months

    Theory of mind was assessed with Happe Strange Stories Test

Sponsors and collaborators

Lead sponsor

University of Deusto

Other

Registry information

Official study title

Implementation of REHACOP Cognitive Training Program in Schizophrenia

Acronym: CSrehacopSZ

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jun 10, 2016
Registry last updated
Jun 10, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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