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Completed

NCT Number: NCT00786617

The Efficacy of Nurse-driven, Protocol Guided Ventilator Weaning in a Medical-Surgical Intensive Care Unit (ICU)

1. Mechanically ventilated patients weaned by nurse-driven ventilator weaning protocol will have a mean length of stay on ventilator at least one day shorter than patients weaned by physician-initiated, non-protocol methods 2. Mechanically ventilated patients weaned by nurse-driven ventilator weaning protocol will have al least similar Ventilator, ICU, and Hospital Length Of Stay (LOS) compared to patients weaned by physician-initiated, non-protocol method 3. Nurse-driven ventilator weaning protocol is well accepted by other services: physicians, nurses, and respiratory therapists.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Ventilatory support is one of the most common indications for admission to ICU (1).

The duration of mechanical ventilation is associated with several serious complications, increase mortality, prolong ICU stay, and increase hospital cost (7,8).

Traditionally, the process of ventilator weaning is initiated and carried out my physicians.

Recently, there have been few studies that supported the utility of protocol guided weaning algorithms. Its use have been associated with earlier initiation of weaning, leading to shorter ventilator time, and a trend for shorter ICU length-of-stay and lower hospital costs (1,2,4,9) Several studies have also shown the relative safety of utilizing nursing (3) and RT staff alone or in cooperation with medical staff in the weaning of patients from mechanical ventilation (1,2,6).

We recently developed a nurse-driven ventilator weaning protocol for all ICUs at St. Luke's and Roosevelt hospitals. The protocol was approved by the Critical Care Committee and is implemented as of May 2007. All ICU nurses, respiratory therapists, and ICU physicians have been educated on this protocol We plan to prospectively collect data to look at length of stay on mechanical ventilation in patients weaned by nurse-driven ventilator weaning protocol. We plan to compare such data to retrospectively collected ventilator LOS data in patients weaned by physician-initiated ventilator weaning method.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Receiving MV for at least 24 hours in the ICU
  • Meeting established protocol criteria for a vent wean trial

Exclusion criteria

  • Patients in whom MV was actively withdrawn for terminal wean
  • Brain dead patients on MV
  • Age <18 years old
  • Transfers from other hospitals or health care facility who were ventilator dependent

Treatment and study plan

Primary outcomes

  1. Average Length of Stay on Ventilator

    Time frame: up to 5 months

Secondary outcomes

  1. ICU mortality

    Time frame: up to 5 months

  2. Hospital mortality

    Time frame: up to 5 months

  3. Treatment intensity and resource allocation: Cost of ICU care per year

    Time frame: up to 5 months

  4. Level of acceptance of nurse-driven vent weaning protocol

    Time frame: up to 5 months

Sponsors and collaborators

Lead sponsor

St. Luke's-Roosevelt Hospital Center

Other

Registry information

Official study title

The Efficacy of Nurse-driven, Protocol Guided Ventilator Weaning in a Medical-Surgical ICU

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Nov 6, 2008
Registry last updated
Mar 20, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.