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Completed

NCT Number: NCT00242671

The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane

The twilight phase between being asleep and awake during recovery from anesthesia is a precarious time fraught with risks to the post-operative patient. Hyperventilation accelerates the elimination of inhaled anesthetics but reduces their CO2 blood concentrations which delays their resumption of spontaneous breathing. We previously showed that our method of hyperventilation without affecting the CO2 concentration--which we call IH--accelerates the rate of emergence from anesthesia with isoflurane. In this study we will study the effect of IH on the rate of emergence from Sevoflurane anesthesia.

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Key information

Conditions

Anesthesia Hyperventilation Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–80 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

Toronto General Hospital, University Health Network

Toronto, Ontario, M5G 2C4, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Elective gynecological procedure
  • ASA I-III
  • Age 18-80 years
  • Signed informed consent

Exclusion criteria

  • ASA IV
  • Patients with contra-indications to Sevoflurane anesthesia or other anesthetics included in the protocol
  • Active smoking, asthma or other history of hyper-reactive airway disease
  • History of chronic obstructive lung disease limiting exercise
  • History of angina, previous myocardial infarction, valvular heart disease, or heart surgery
  • Presence of heart murmurs or neck bruits
  • ECT abnormalities including atrial fibrillation, prolonged P-R interval, prolonged Q-T interval, presence of Q waves in inferior, anterior or lateral leads, criteria for left ventricular hypertrophy, T-wave abnormalities,
  • History of difficult airway access
  • Pulmonary hypertension and/or right ventricle dysfunction
  • History of bulous emphysema, and/or spontaneous pneumothorax
  • History of alcohol or drugs abuse
  • Known history of psychiatric illness and/or medications
  • Patients that required postoperative mechanical ventilation for any reason

Treatment and study plan

Isocapnic Hyperponea

Procedure

Primary outcomes

  1. Time to recovery from anesthesia as indicated by time to extubation and rate of change of BIS score

Secondary outcomes

  1. Quality of recovery in the recovery room as indicated by the level of consciousness, incidence of nausea, vomiting, shivering and other phenomena occuring during recovery

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Registry information

Official study title

The Efficacy of Isocapnic Hyperpnoea to Accelerate Recovery After General Anesthesia With Sevoflurane.

Important dates

Study start
2005
Primary completion
2008
Study completion
2008
First posted
Oct 20, 2005
Registry last updated
Aug 5, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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