The Efficacy and Safety of Temporal Interference Stimulation on Motor Symptoms of Parkinson's Disease

Inclusion criteria

• Age >= 40 years;
• Meet the diagnostic criteria for primary Parkinson's disease (MDS Parkinson's Disease Diagnostic Criteria (2015 Edition));
• No medication adjustment in the 4 weeks before and during each stimulation;
• MDS-UPDRS III score >= 8 points, Hoehn-Yahr score 1-4 points

Exclusion criteria

• Focal brain injury or severe leukoencephalopathy (Fazekas grade 3 or above) on previous head MRI/CT scans;
• Various secondary Parkinson's syndromes (vascular Parkinson's syndrome, drug-induced Parkinson's syndrome, etc.);
• Severe craniocerebral trauma, cranial surgery or deep brain stimulation treatment;
• Ferromagnetic implants in the body, such as cochlear implants, cardiac pacemakers, etc.;
• A history of epilepsy, unexplained loss of consciousness, or taking anticonvulsant drugs for epileptic seizures;
• Diagnosed with neuropsychiatric diseases other than Parkinson's disease;
• A history of drug abuse or drug use;
• Participated in any clinical trial in the past 3 months;
• Pregnant/lactating women or subjects (including men) who plan to have children within 6 months;
• Other situations that the researchers consider unsuitable for inclusion.