The Efficacy and Safety of HRS8179 in Severe Cerebral Edema Following Large Hemispheric Infarction

Inclusion criteria

• Fully understand and voluntarily participate in this trial, and sign the informed consent form (the informed consent form can be signed voluntarily by the participant or their legal representative);
• A clinical diagnosis of acute ischemic stroke in the middle cerebral artery (MCA) territory;
• National Institutes of Health Stroke Scale (NIHSS) ≥ 10 at screening;
• A large hemispheric infarction defined as: lesion volume of 80 to 160 cm3 on magnetic resonance imaging (MRI) diffusion-weighted imaging (DWI), or computed tomography perfusion (CTP).
• The time from onset to treatment must be ≤ 10 hours; if the onset time is unknown, treatment must be initiated within 10 hours after the time last known normal.

Exclusion criteria

• Theparticipant is likely to withdraw the supportive treatment on the first day;
• There is evidence indicating a concurrent infarction in the contralateral hemisphere sufficiently serious to affect functional outcome.
• There are clinical signs of brain herniation; CT/MRI indicates a midline shift of >2 mm; CT/MRI indicates cerebral hemorrhage;