Skip to main content
OpenTrials
Completed

NCT Number: NCT06103045

The Effects of Unilateral and Bilateral Mirror Therapy on Upper Extremity Function in Early Subacute Stroke.

Objective: To comparing the effects of unilateral and bilateral mirror therapy on upper extremity function of stroke at early subacute stage. We hypothesize there are different effects between unilateral and bilateral mirror therapy on stroke patients at early subacute stage. Method: Patients with unilateral stroke and the onset within one month will be recruited and then randomly allocated to one of the three groups (including unilateral mirror therapy, bilateral mirror therapy, and conventional occupational therapy). Patient will receive 20 consecutive sessions of intervention (5 time per week, totally 4 weeks) and assessments before and after the intervention within one week. In each intervention session, patients will receive 30 minutes unilateral or bilateral mirror therapy depending on their allocated groups and then 30 conventional occupational therapy. The patients recruited in the conventional occupational therapy group will receive 60 minute conventional therapy. The outcome measures at pre- and post-treatment will including the Fugl-Meyer Assessment for upper extremity (FMA-UE), the Modified Ashworth Scale (MAS), the Jamar Hydraulic Hand Dynamometer, the Chedoke Arm and Hand Activity Inventory (CAHAI), and the Revised Nottingham Sensory Assessment (rNSA).

Completed

Looking for future studies?

Notify Me

Key information

Age range

20 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University Hospital Hsin-Chu Branch

Hsinchu, 300, Taiwan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Unilateral stroke onset within 1 month
  • The score of Mini-Mental State Examination (MMSE) is more than 24
  • The score of Fugl-Meyer Assessment for upper extremity (FMA-UE) is between 18 to 56
  • The score of Modified Ashworth Scale (MAS) is less than 3
  • Willing to receive 3-5 sessions of the intervention per week, total 20 sessions consecutively
  • Willing to sign informed consent

Exclusion criteria

  • Unstable vital sign or complicating with other symptoms of neurological disease
  • Auditory or visual function impairment
  • Complicating with perceptual impairment (e.g., apraxia, neglect, or visual agnosia)
  • Receiving botulinum toxin injection within 3 months
  • Complicating with Wernicke's or Broca's aphasia

Treatment and study plan

unilateral and bilateral mirror therapy

Other

The mirror box is placed on a table in the sagittal plane of the participant. The affected upper extremity of the participant is hidden in the morror box and the unaffected upper extremity is placed symmetrically. During the unilateral or bilateral mirror therapy, the participant is requested to execute a serial of movements and tasks and pay attention on observing the reflection of the unaffected side in the mirror simultaneously. In the bilateral mirror therapy, the participant also has to move the affected upper extremity simultaneously; while in the unilateral mirror therapy, the participant only keeps the affected side relaxed.

Primary outcomes

  1. Fugl-Meyer Assessment for upper extremity (FMA-UE)

    Time frame: pre-treatment: before intervention within a week; post-treatment: after intervention within a week

    The FMA-UE is a commonly used assessment in clinical for the extent of motor impairment of upper extremity post-stroke. The score ranged from 0 to 66. The psychometric properties of the FMA-UE had established, and there was also good responsiveness in the past studies.

  2. The Jamar Hydraulic Hand Dynamometer

    Time frame: pre-treatment: before intervention within a week; post-treatment: after intervention within a week

    The Jamar Hydraulic Hand Dynamometer is a gold standard assessment tool for measuring muscle power including the grip strength, palmar pinch, and lateral pinch.

Secondary outcomes

  1. Modified Ashworth Scale (MAS)

    Time frame: pre-treatment: before intervention within a week; post-treatment: after intervention within a week

    The MAS is a clinical measurement for muscle spasticity. The score is ranged from 0 to 4. The shoulder, elbow, forearm, wrist, and fingers will be assessed. The psychometric properties of the MAS had established in the past studies.

  2. Chedoke Arm and Hand Activity Inventory (CAHAI)

    Time frame: pre-treatment: before intervention within a week; post-treatment: after intervention within a week

    The CAHAI is used for the involvement of the impairment upper extremity during the bimanual tasks. There are 13 item and each score is ranged from 1-7. The psychometric properties of the CAHAI had established in the past studies.

  3. Revised Nottingham Sensory Assessment (rNSA)

    Time frame: pre-treatment: before intervention within a week; post-treatment: after intervention within a week

    The rNSA is developed for assessing sensory function of patients with stroke. The reliability of rNSA was established in the past study.

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital Hsin-Chu Branch

Other

Registry information

Official study title

The Effects of Unilateral and Bilateral Mirror Therapy on Upper Extremity Function in Early Subacute Stroke: A Pilot Randomized Controlled Trial.

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Oct 26, 2023
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.