The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women

Inclusion criteria

• Between the ages of 50-70 and at least 1 year beyond menopause;
• resting blood pressure <140/90 mmHg;
• plasma glucose concentrations <110 mg/dL under fasting conditions;
• BMI < 35;
• LDL cholesterol < 160 mg/dL;
• sedentary or recreationally active (<3 days of vigorous aerobic exercise);
• no use of OCs, HT, or other medications that might influence cardiovascular function;
• nonsmokers;
• no use of vitamin supplements, blood thinners or NSAIDS, or willing to stop use one month prior to and for the duration of the study;
• not taking any other medications that would interact with E2 patch or resveratrol to confound interpretation of results.

Exclusion criteria

• history of or active E2-dependent neoplasms, acute liver or gallbladder disease, vaginal bleeding, venous thromboembolism, hypertriglyceridemia (≥ 150 mg/dL), and CVD;
• known allergy to transdermal patch, or resveratrol;
• history of stomach ulcer or bleeding;
• other contraindications to HT or resveratrol.
• other conditions for which individuals will be excluded from the study include: diabetes, active infection, history of seizures or disease that affects the nervous system or an abnormal resting ECG.