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OpenTrials
Completed

NCT Number: NCT01130129

The Effects of Plant Bioactives on Platelet Function

Consumption of a diet rich in fruit and vegetables is associated with a reduced risk of cardiovascular disease and the protective effect may be due to polyphenolic compounds contained within these foods. The mechanism by which polyphenols exert this effect is not clearly understood but research has focused on their potential to affect platelet function. The purpose of this study is to quantify the anti-clotting activity of a range of plant food extracts and component compounds.

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Key information

Conditions

Healthy

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Institute of Food Research

Norwich, Norfolk, NR4 7UA, United Kingdom

About this study

A single sample of whole blood will be collected from 15 male or female volunteers aged between 18 and 65 years. After collection whole blood will be treated with a range of flavonoids to evaluate their effects on platelet function.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females
  • Aged 18 - 65 years.
  • BMI > 19.5 and < 35
  • Non-smokers

Exclusion criteria

  • Pregnancy or have been pregnant within the last 12 months
  • Parallel participation in another research project which involves dietary intervention
  • Participation in another research project which has involved blood sampling within the last four months unless the total amount of combined blood from both studies does not exceed 470 mls.
  • Has donated or intends to donate blood within 16 weeks prior to during the Study period.
  • Depressed or elevated blood pressure measurements (<90/50 or 95/50 if symptomatic or >160/100)
  • Any person related to or living with any member of the study team
  • Diabetics
  • Taking regular prescribed and/or non-prescribed medication (excluding oral contraceptive and HRT).
  • Known bleeding disorders.

Treatment and study plan

Ex-vivo treatments with flavonoids

Other

Ex-vivo treatment of platelets with a range of flavonoids

Primary outcomes

  1. Identification of flavonoids that exert a significant anti-clotting effect

    Time frame: within 4hours

Sponsors and collaborators

Lead sponsor

Quadram Institute Bioscience

Other

Collaborators

  • European Union

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
May 25, 2010
Registry last updated
Mar 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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