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Completed

NCT Number: NCT02051127

The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.

One of the biggest challenges of today is the high stress levels among employees in companies and organizations. Physical exercise may be an effective preventive measure for stress-related problems. This relatively simple and inexpensive action is believed to be important for increasing and maintaining work ability and reduce the cost of stress-related ill health in the workplace.

The aim is to investigate how regular physical exercise affects the individual's ability to mentally and physiologically cope with stress. Acute stress physiological responses are measured before and after a 6 -month intervention, where 100 untrained individuals are randomized to either regular physical exercise or a control group.

The hypothesis is that exercise leads to lesser activation of the individual's stress physiological systems and to an efficient physiological protection system. Mental ability to handle stress is also studied as well as possible effects on the brain's cognitive functions. From a work perspective, cognitive impairment due to high exposure to stress is a major problem leading to substantial costs in businesses and organizations as a result of reduced performance and production.

We believe that physical activity can alter and mitigate individual stress reactions. This study brings new knowledge that can contribute to increased motivation to prioritize physical activity in everyday life. The study could also provide evidence for businesses and organizations of the benefits of engaging in interventions and fitness initiatives to facilitate/enable increased physical activity in daily life for its employees. With an aging population, we are expected to work longer, which poses a challenge as the ability to manage stress and maintain cognitive abilities decline with age. For older employees, regular physical activity could be an important factor directly affecting the prospects for a sustainable working life.

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Key information

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Institute of Stress Medicine

Gothenburg, VGR, SE-413 19, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Self-reported good health
  • Sedentary
  • Work or study at least 50%

Exclusion criteria

  • Diabetes
  • Cardiovascular disease
  • Blood pressure > 140/90
  • Psychiatric disease
  • Anemia
  • Medication with substances that could affect any of the outcome measures

Treatment and study plan

Exercise

Other

Physical training Duration: 45-60 minutes Frequency: 3 times per week Intensity: mean heart rate > 75% of maximum heart rate determined by exercise test before start of the intervention

Primary outcomes

  1. Cortisol responses to acute psychosocial stress.

    Time frame: 6 months after start of intervention

    Serum cortisol (nmol/l) profile after exposure to the Trier Social Stress Test (TSST).

Secondary outcomes

  1. Cognitive function

    Time frame: 6 months after start of intervention

    Performance of the CNS Vital Signs (CNSVS) cognitive test battery.

  2. Self-reported stress sensitivity and symptoms

    Time frame: 6 and 12 months after start of intervention

    Assessed with the Perceived Stress Scale (PSS), Coping Inventory for Stressful Situations (CISS), Shirom Melamed Burnout questionnaire (SMBQ), Hospital Anxiety and Depression scale (HAD) and Patient Health Questionnaire (PHQ-15).

  3. Adrenocorticotropic hormone (ACTH) response to psychosocial stress

    Time frame: 6 months after start of intervention

    ACTH in plasma (pmol/L) after exposure to the TSST

  4. Dehydroepiandrostreone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) response to psychosocial stress

    Time frame: 6 months after start of the intervention

    DHEA(S) in serum (µmol/L) after exposure to the TSST

Other outcomes

  1. Autonomic responses to acute psychosocial stress

    Time frame: 6 months after start of intervention

    Heart rate and blood pressure during and after the Trier Social Stress Test (TSST).

  2. Neuroendocrine and autonomic responses to exercise test

    Time frame: 6 months after start of intervention

Sponsors and collaborators

Lead sponsor

Vastra Gotaland Region

Other Gov

Registry information

Official study title

Sustainable Working Life With Reduced Stress Levels - The Effects of Physical Training on Physiological and Psychological Stress-reactions and Cognitive Function.

Acronym: ASTI

Important dates

Study start
2013
Primary completion
2016
Study completion
2017
First posted
Jan 31, 2014
Registry last updated
Oct 11, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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