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NCT Number: NCT06507280

The Effects of Periodontal Therapy on Gingival Crevicular Fluid NLRP3,Caspase-1,IL-1β Levels in Children With Gingivitis

This study aims to determine the levels of NLRP3, caspase-1 and IL-1β concentrations in the gingival crevicular fluid of paediatric patients with gingivitis and their changes after periodontal treatment.

Recruiting

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Key information

Age range

11 year–14 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sultan Keles

Aydin, 09100, Turkey (Türkiye)

Location status: Recruiting

Location contact

Nazlı Sevilmiş

SUB_INVESTIGATOR

Sultan Keles, Assoc.Prof.dr

CONTACT

[email protected]

05318438557

About this study

After being informed about the study and potential risks, necessary periodontal measurements will be performed and gingival crevicular fluid will be collected from all patients who gave written informed consent, and patients with gingivitis will be followed up on the 7th and 30th day after periodontal treatment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion criteria

for the group with gingivitis;

  • Systemically healthy
  • 11-14 years old
  • Permanent dentition
  • No need for endodontic and restorative treatment
  • Gingivitis with gingivitis
  • Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.

Inclusion criteria

for the healthy group;

  • Systemically healthy
  • 11-14 years old
  • Permanent dentition
  • No need for endodontic and restorative treatment
  • Periodontally healthy
  • Have verbally and in writing agreed to participate in the study and are willing to attend follow-up appointments regularly participants will be included in the study.

Exclusion criteria

  • In need of endodontic and restorative treatment
  • Systemically unhealthy
  • Patients who do not give verbal or written consent

Treatment and study plan

Periodontal theraphy

Procedure

periodontal therapy

Primary outcomes

  1. NLRP3

    Time frame: Baseline

    NOD-, LRR- and pyrin domain-containing protein 3 level

  2. Caspase-1

    Time frame: Baseline

    Caspase-1 level

  3. IL-1 Beta

    Time frame: Baseline

    Interleukin-1 Beta level

Secondary outcomes

  1. NLRP3

    Time frame: 7. days - 30. days

    NOD-, LRR- and pyrin domain-containing protein 3 level

  2. Caspase-1

    Time frame: 7. days -30. days

    Caspase-1 level

  3. IL-1 Beta

    Time frame: 7. days-30. days

    Interleukin-1 Beta level

Study contacts

Contact information is provided by the study sponsor or research team.

Sultan Keleş, Assoc.Prof.

CONTACT

[email protected]

05318438557 ext. +90

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Jul 18, 2024
Registry last updated
Jul 18, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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