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NCT Number: NCT07528469

The Effects of PeptiStrong and Whey on Muscle Function In Older Adults

Examining the effects of PeptiStrong and protein on muscle function in older adults

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Key information

Conditions

Healthy Ageing Hand Grip Strength Longevity Muscle Function Muscle Health Peptides Protein Supplementation

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

LJMU, Byrom Street

Liverpool, L3 3AF, United Kingdom

Location status: Recruiting

Location contact

Graeme Close, Prof.

CONTACT

[email protected]

0151 231 2121

About this study

The aim of this study is to compare two protein drinks containing whey protein (derived from milk) in healthy adults aged 60 to 85 years. One group will consume a standard whey protein drink (20g), while the other group will consume a drink with half the total protein dose (10g) made of whey protein and PeptiStrong, a fava bean hydrolysate containing bioactive peptides.

The study will assess whether the lower protein drink containing PeptiStrong will lead to equal or greater improvements than the standard drink in physical function, such as the ability to stand up from a chair, walk at a normal pace, maintain balance, and grip strength. The study will also examine markers related to inflammation, fatigue, and quality of life.

The intended value of this research is to improve understanding of how targeted nutritional strategies may help maintain or improve muscle function in older adults. The findings may help inform future nutritional recommendations and the development of practical dietary interventions aimed at supporting healthy ageing and independence.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women aged 60 to 85 years at the time of enrolment
  • Community-dwelling (living independently or with minimal assistance)
  • Able to walk independently (with or without a walking aid) and complete simple physical function tests (such as standing up from a chair and walking short distances)
  • Willing and able to attend two study visits at the research facility (baseline and end of study)
  • Willing and able to consume a protein drink containing whey protein (derived from milk) once daily for 30 days
  • Able to understand the study information and provide written informed consent

Exclusion criteria

  • Any known food allergy or intolerance to fava bean protein or milk protein
  • Diagnosed kidney disease or any medical condition where increased protein intake is contraindicated
  • Yes to any of the answers on the "Older Adult Functional Assessment Screening Questionnaire"
  • Individuals with implanted electronic devices
  • Current or recent (within the past 3 months) participation in another clinical research study involving a nutritional or exercise intervention
  • Conditions that significantly impair mobility or balance such that safe completion of the physical function tests is not possible

Treatment and study plan

PeptiStrong + whey protein

Dietary Supplement

Fava bean protein hydrolysate containing bioactive peptides mixed with whey protein as dry powder for drinkable protein shake

Whey Protein

Dietary Supplement

Whey protein as dry powder for drinkable protein shake

Primary outcomes

  1. Hand Grip Strength via hand held dynamometer

    Time frame: Baseline to Week 4

    Change from baseline to end of study in grip strength as assessed via hand held dynamometer

Secondary outcomes

  1. Chair Stand Test - Part of short performance physical battery

    Time frame: Baseline to week 4

    Change from baseline to end of study in physical function assessment via chair stands. This test measures the time taken to complete 5 sit-to-stand repetitions in seconds. A lower time (fewer seconds) = better performance. As part of the full short performance physical battery it is converted to a subscore of 0-4, where a higher score = better performance

  2. Gait Speed as part of short performance physical battery

    Time frame: Baseline to week 4

    Change from baseline to end of study in physical function assessment assessed as time to walk a fixed distance in seconds and reporting in meters per second. Higher speeds indicate better performance. This is converted to a subscore of 0-4 within the full short performance physical battery

  3. 6 Minute Walking Endurance Test

    Time frame: Baseline to week 4

    Change from baseline to end of study in physical function and endurance assessed as the total distance walked in 6 minutes in meters. A greater distance reflects better walking endurance and functional capacity.

  4. Balance test as part of short performance physical battery

    Time frame: Baseline to week 4

    Change from baseline to end of study in balance as assessed by the ability to hold three standing positions of increasing difficulty: side-by-side, semi-tandem, and tandem stance in seconds. Higher scores indicate better balance. The overall score is converted to a a sub-score of 0-4 within the full short performance physical battery.

  5. Balance assessment via force plates

    Time frame: Baseline to week 4

    Change from baseline to end of study in balance as assessed via force plates

  6. Quality of Life via the Sarcopenia Quality of Life (SarQoL®) Questionnaire

    Time frame: Baseline to week 4

    Change from baseline to end of study in quality of life as measured via subjective SarQOL questionnaire. The total score ranges from 0 to 100, with higher scores reflecting a higher quality of life.

  7. Fatigue via Multidimensional Fatigue Inventory Questionnaire

    Time frame: Baseline to week 4

    Change from baseline to end of study in self-reported fatigue as assessed via multidimensional fatigue inventory questionnaire. This 20-item questionnaire covers five dimensions: General Fatigue, Physical Fatigue, Mental Fatigue, Reduced Motivation, and Reduced Activity. Each subscale score ranges from 4 to 20, with higher scores indicating greater fatigue

  8. C-reactive protein (CRP) via blood test

    Time frame: Baseline to week 4

    Change from baseline to the end of study in inflammatory marker C-reactive protein (CRP) in serum as mg/L

  9. Interleukins via blood test

    Time frame: Baseline to week 4

    Change from baseline to the end of study in Interleukin inflammatory markers in serum as pg/mL

  10. Body composition: Muscle mass and body fat via bioelectrical impedance analysis

    Time frame: Baseline to week 4

    Change from baseline to end of study in muscle mass and body fat as measured by bioelectrical impedance analysis in kilograms and % of total body weight

Study contacts

Contact information is provided by the study sponsor or research team.

Niamh Mohan, PhD

CONTACT

[email protected]

+353 1 430 1290

Sponsors and collaborators

Lead sponsor

Nuritas Ltd

Industry

Collaborators

  • Liverpool John Moores University

Registry information

Official study title

The Effects of PeptiStrong and Low Dose Whey Protein Versus High Dose Whey Protein Alone on Muscle Function In Older Adults

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 14, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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