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Completed

NCT Number: NCT01211717

The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients

The purpose of this study is to determine the effectiveness of the 3 Branched Chained Amino Acids (isoleucine, leucine, and valine) on treating Delayed Onset Muscle Soreness, a type of muscle pain which usually develops after exercising.

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Key information

Conditions

Type 2 Diabetes Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Healthy Individuals Metabolic Diseases Nutritional and Metabolic Diseases

Age range

20 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Loma Linda University, School of Allied Health Professions

Loma Linda, California, 92354, United States

About this study

Delayed Onset Muscle Soreness is a common painful sensation experienced by individuals who have been recently inactive and begin with an unaccustomed exercise protocol. Branched Chained Amino Acids have been found as a useful supplement for promoting muscle recovery following exercise; however the effects of this supplement have not been investigated amongst individuals with diabetes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The subjects with diabetes must have been diagnosed with diabetes at least one year before the onset of the study
  • At least 6 weeks of physical inactivity in the upper body
  • BMI less than 40

Exclusion criteria

  • For the Diabetics, hemoglobin A1c levels over 13
  • Pregnant
  • Have Cardiovascular diseases
  • Have Hepatic diseases
  • Are diagnosed with Rhabdomyolysis
  • Recent upper limb injuries
  • Upper limb neuropathy
  • Blood Pressure levels over 140/90, or lower than 90/60
  • Are on High doses of alpha or beta agonist/antagonists, and take any types of NSAID's, Cox 2 inhibitors, Calcium channel blockers, Pre-Gabalin's, or Pain reducers

Treatment and study plan

Branched Chained Amino Acids

Dietary Supplement

Two doses of the Branched Chained Amino Acid supplement will be taken. The first dose will be taken 35 minutes before the intended exercise, and the other dose will be taken right after completing the exercise. The amount of the Branched Chained Amino Acid supplement administered to the subjects in the experimental group will vary from one person to the other but a total dose of 1 gram of BCAA per kilogram of lean body mass will be used. This dose will be divided in half and administered at the two specified occasions. The ratio of isoleucine, leucine, and valine will be 1:2.5:1 respectively

Other names: Isoleucine, Leucine, and Valine

Cellulose Placebo mix

Other

The control group will also take 2 doses, 1 before the exercise, and the other after completing the exercise. This dose will be divided in half and administered at the two specified occasions.

Primary outcomes

  1. Measuring Pain, using the short form McGill pain questionnaire

    Time frame: 5 days following the initial exercise

Secondary outcomes

  1. Measuring Muscle strength of the studied muscle

    Time frame: 5 days following the initial exercise

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Sep 29, 2010
Registry last updated
Apr 22, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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