The Effects of Morphine on Desflurane Consumption and Recovery Time

Combination of volatile and opioid agents are used to achieve unconsciousness, haemodynamic stability and analgesia for surgical prosedures. This prospective, randomized, double-blind, controlled study evaluates the effects of two different doses of morphine sulphate (0.1 mg/kg and 0.2 mg/kg), on desflurane consumption, recovery characteristics, postoperative analgesic requirements and side effects during total abdominal hysterectomy.

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Key information

Conditions

Abdominal Hysterectomy (& Wertheim)

Age range

40 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Baskent University School of Medicine Adana Teaching and Research Hospital

Adana, 01250, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

undergoing total abdominal hysterectomy with general anaesthesia

Exclusion criteria

renal dysfunction (cre>1.2), liver failure, cardiovascular, psychiatric, allergic and metabolic disorders

Treatment and study plan

Morphine

Drug

Group Saline (Group S): Received i.v saline 0.9 % in 10 ml volume (n=30) Group Morphine 1 (Group M1): Received i.v morphine 0.1 mg kg-1 in 10 ml volume (n=30) Group Morphine 2 (Group M2): Received i.v morphine 0.2 mg kg-1 in 10 ml volume (n=30)

Primary outcomes

postoperative desflurane consumption

Time frame: postoperative first hour
sedation scores for OASS scale

Time frame: postoperative first hour

Sponsors and collaborators

Lead sponsor

Baskent University

Other

Registry information

Official study title

Comparison of Two Different Doses of Intravenous Morphine on Desflurane Consumption and Recovery Time in Patients Undergoing Total Abdominal Hysterectomy

Important dates

Study start: 2007
Primary completion: 2007
Study completion: 2007
First posted: Feb 12, 2015
Registry last updated: Dec 3, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed