The Effects of Linezolid and Vancomycin on Inflammation and Cellular Signaling Vents

We will determine if linezolid inhibits cellular activation and production of pro-inflammatory cytokines, providing mechanistic rationale for its clinical efficacy and the justification for further investigations in S. Aureus sepsis.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy, taking no medications, and not recently hospitalized

Exclusion criteria

Infection (active)

Treatment and study plan

Linezolid or Vancomycin

Drug

Whole blood samples from healthy subjects will be incubated with MRSA bacterium or bacterial toxins in the presence and absence of either linezolid or vancomycin. Final concentrations will mimic physiologic conditions. Platelets and leukocytes will be isolated and assayed for the presence of absence of activation and pre-mRNA splicing.

Other names: Zyvox

Primary outcomes

IL-6

Time frame: 12 Months

Measurement of IL-6 release in response to MRSA.

Secondary outcomes

MCP-1

Time frame: 12 Months

Measurement of MCP-1 release in response to MRSA.

Sponsors and collaborators

Lead sponsor

University of Utah

Other

Collaborators

Pfizer

Registry information

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Dec 19, 2008
Registry last updated: Nov 24, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed