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Completed

NCT Number: NCT02974894

The Effects of Lactobacillus Plantarum on Cortisol, IgA and Alpha-amylase Levels in Human Saliva During Stress

In the present study the main goal has been to clarify the effect of the probiotic bacteria Lactobacillus plantarum 299v on the salivary cortisol level in young adults under examination stress. Salivary IgA from minor glands and in whole human saliva was measured as alternative marker of stress. The hypothesis was that the levels of cortisol would be reduced or stabilized in the test group in comparison to the placebo group where the cortisol levels were expected to increase due to the examination-induced stress. By contrast, the salivary IgA levels were expected to increase in the test group in comparison to the placebo group.

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Key information

Conditions

Stress Reaction Fractures, Bone Fractures, Stress Wounds and Injuries

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adults
  • studying at the University in Lund
  • participation in ongoing examination period

Exclusion criteria

  • pregnancy
  • intake of antibiotics
  • medication with cortisone during the study period

Treatment and study plan

Probiotic (Lactobacillus Plantarum)

Dietary Supplement

Placebo

Dietary Supplement

Primary outcomes

  1. The impact of Lactobacillus plantarum on the levels of stress-induced cortisol in saliva.

    Time frame: Change from baseline in cortisol levels at 14 days

Sponsors and collaborators

Lead sponsor

Lund University

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Nov 29, 2016
Registry last updated
Dec 1, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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