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Completed

NCT Number: NCT02259049

The Effects of L-Tyrosine on 24 Hour Blood Pressure and Heart Rate in Parkinson's Disease

The investigators are observing the effects 2,000 mg of L-tyrosine will have on 24 hour blood pressure fluctuations in individuals with Parkinson's disease.

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Key information

Conditions

Blood Pressure

Age range

40 year–84 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

New York Institute of Technology

Old Westbury, New York, 11758, United States

About this study

We will be monitoring 24 hour ambulatory BP and HR in subjects with PD on 3 separate visits. The first visit will be without an intervention to establish a baseline of 24 hour BP fluctuations. One week later the subject will be given either L-tyrosine (2,000 mg) with B6 (10 mg) or a sugar pill. We will monitor 24 hour BP and HR after supplementation. One week later the subject will repeat the same procedures with either supplement or placebo.

This is a total of 3 visits with 24 hour ambulatory BP and HR monitoring.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All subjects must have a diagnosis of PD by a licensed neurologist according to the UK Parkinson's Disease Society Brain Bank Clinical Diagnostic Criteria (UKPDBB).(Goetz, 2010) The UKPDBB is a 3 step diagnostic tool which defines inclusion and exclusion criteria for diagnosing PD
  • between 35 and 79 years of age
  • mentally able to participate in the study

Exclusion criteria

  • Pregnancy
  • any person who is currently taking amino acid supplements.
  • Any history of myocardial infarction, stent, or CABG
  • Phenylketonurics
  • Untreated hypertension

Treatment and study plan

L-tyrosine

Dietary Supplement

Each subject will receive 2,000 mg of L-tyrosine BID for 24 hours.

Sugar Pill

Dietary Supplement

Each subject will receive a sugar pill BID for 24 hours.

Primary outcomes

  1. Blood Pressure

    Time frame: 24 hours

Secondary outcomes

  1. Heart Rate

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

New York Institute of Technology

Other

Registry information

Official study title

The Effects of L-Tyrosine on Non-invasive Ambulatory Blood Pressure and Heart Rate Monitoring in Parkinson's Disease

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Oct 8, 2014
Registry last updated
Jan 20, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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