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Completed

NCT Number: NCT01801540

The Effects of L-arabinose in a Meal in Healthy Men

The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.

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Key information

Conditions

Glucose Metabolism

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male
  • normal weight (BMI 18,5-25 kg/m2)
  • 18-30 years of age

Exclusion criteria

  • Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders
  • Central adipositas (defined as waist circumference > 94 cm for european men)
  • Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.
  • elevated alcoholcunsumption(> 21 units af alcohol pr. week)
  • take medicine
  • Elite athlete with intensive training
  • given bloddonation within the last 3 months
  • smoking

Treatment and study plan

L-arabinose - effect on glucose metabolism

Dietary Supplement

L-arabinose is mixed into the dough of the buns and cup cakes

Primary outcomes

  1. Glucose

    Time frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min

    Level of glucose over time, The AUC, the peak value and time to peak

  2. Insulin

    Time frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min

    Level of insulin over time, the AUC, the peak value and time to peak

  3. C-peptide

    Time frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min

    Level of c-peptide over time, The AUC, the peak value and time to peak

Secondary outcomes

  1. Glucagon

    Time frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min

    Level of glucagon over time, The AUC, the peak value and time to peak

  2. GLP-1

    Time frame: -15, 0, 15, 30, 45, 60, 90, 120, 180 min

    Level of GLP-1 over time, The AUC, the peak value and time to peak

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Official study title

The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Feb 28, 2013
Registry last updated
Feb 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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