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Completed

NCT Number: NCT02164448

The Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy

The investigators hypothesized that sympatholytic effect of dexmedetomidine would attenuate the hemodynamic instability and decrease in the splanchnic blood flow caused by pneumoperitoneum during laparoscopic surgery. This study is to investigate the effect of intraoperative dexmedetomidine infusion on postoperative bowel movement in patients undergoing laparoscopic gastrectomy.

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Key information

Conditions

Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine,

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
  • gastric cancer patient undergoing laparoscopic gastrectomy

Exclusion criteria

  • ASA physical status Ⅳ
  • bradycardia (< 60 bpm), arrhythmia
  • uncompensated heart failure
  • hepatic failure (Child-Pugh score B 이상)
  • renal failure (eGFR MDRD < 60 ml/min/1.73m2)

Treatment and study plan

the dexmedetomidine group

Drug

the dexmedetomidine group: dexmedetomidine infusion from induction of anesthesia to end of surgery

the control group

Drug

saline infusion from induction of anesthesia to end of surgery

Primary outcomes

  1. gas passing

    Time frame: up to 1 week

    To evaluate the postoperative bowel movement, we will assess the time to first gas passing

Secondary outcomes

  1. sips of water time

    Time frame: up to 1 week

    To evaluate the postoperative bowel movement, we will assess the time to resume water intake

Other outcomes

  1. soft diet time

    Time frame: up to 1 week

    To evaluate the postoperative bowel movement, we will assess the time to resume soft diet intake

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2014
Primary completion
2015
Study completion
2015
First posted
Jun 16, 2014
Registry last updated
May 27, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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