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NCT Number: NCT06883357

The Effects of Home-based Graded Repetitive Arm Supplementary Program Group on Stroke.

Graded repetitive arm supplementary program (GRASP) is a self administrated, home-based rehabilitation program and has been incorporated in Canadian Stroke Best Practice Recommendations. Past studies indicated that the home-based GRASP program could facilitate the motor function and motor recovery and prevent learned nonuse of affected upper limb of stroke patients. There is lacking of research and application of the home-based GRASP program in Taiwan. Therefore, this study aims to explore the effects of the home-based GRASP program, which is mainly executed in the form of group intervention, on the affected upper limb of stroke patients.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Vascular Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University Hospital Hsin-Chu Branch

Hsinchu, 300, Taiwan

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age is above 20 years old.
  • Onset of first stroke complicated with hemiplegia or hemiparesis.
  • The affected upper limb remains partially voluntary movements including lifting to chest level and holding for five seconds; slight flexion and extension of wrist and hand.
  • Understanding and complying with two-steps commands.
  • Understanding the content of trial and willing to sign informed consent.

Exclusion criteria

  • Complicating with other neurological disease.
  • Having Orthopedic diseases affecting the movements of upper limbs.
  • Having symptoms of pain to affect the movements of upper limbs.
  • Unstable vital sign or medical condition.
  • Participating another rehabilitative or drug research meanwhile.
  • Receiving botulinum toxin injection within three months.

Treatment and study plan

Graded repetitive arm supplementary program (GRASP)

Behavioral

Graded repetitive arm supplementary program (GRASP) is a self administrated, home-based rehabilitation program. home-based GRASP program could facilitate the motor function and motor recovery and prevent learned nonuse of affected upper limb of stroke patients. Participants in experimental group will receive Home GRASP program which will be executed 1hour at home per day. In addition, Participants will be requested to return hospital for follow-up and adjusting the training program in group discussion 3 times per week, lasting 4-6 weeks, and totally 12-18 sessions.

Primary outcomes

  1. Fugl-Meyer Assessment for upper extremity (FMA-UE)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Fugl-Meyer Assessment for upper extremity (FMA-UE) includes 33 items for the motor recovery of upper limb. Each item is a 3 point ordinal scale. The total score ranges from 0 to 66, higher score means better motor recovery.

  2. Jamar Hydraulic Hand Dynamometer (Jamar Dynamometer)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Jamar Hydraulic Hand Dynamometer (Jamar Dynamometer) is a tool used for assessing the strength of grip, lateral pinch, and palmar pinch. The muscle strength is recorded in kilograms or pounds.

  3. Action Research Arm Test (ARAT)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Action Research Arm Test (ARAT) is developed for measuring the motor function of affected upper limb after stroke. ARAT includes subscales of grasp, grip, pinch, and gross movement. The total score ranges from 0 to 57, higher score means better motor function.

Secondary outcomes

  1. Chedoke Arm and Hand Activity Inventory (CAHAI)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Chedoke Arm and Hand Activity Inventory (CAHAI) is developed for measuring the level of function and involvement of the affected upper limb in bimanual tasks. It contains 13 tasks and the total score is ranged from 13 to 91. The higher score means better motor function and involvement.

  2. Rating of Everyday Arm-use in the Community and Home Scale (REACH-Scale)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Rating of Everyday Arm-use in the Community and Home Scale (REACH-Scale) is a self-evaluation scale designed for stroke patients to measure the involvement of the affected upper extremity in everyday life. The score ranged from 0 to 5 and higher score indicate the more utilization of affected upper extremity.

  3. Stroke Impact Scale Version 3.0 (SIS 3.0)

    Time frame: From enrollment to the end of treatment at 6 weeks

    The Stroke Impact Scale Version 3.0 (SIS 3.0) is a self-evaluated assessment for measuring the quality of life of patients with stroke. In our study, the strength domain(total score:4-20) and hand function domain(total score:5-25), and the an extra question on stroke recovery(total score:0-100)was used. The higher score means better quality of life.

Study contacts

Contact information is provided by the study sponsor or research team.

Chia-Yi Lin

CONTACT

[email protected]

+886-3-5326151#523509

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

The Effects of Home-based Graded Repetitive Arm Supplementary Program Group on Stroke: the Randomized Controlled Trial.

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 19, 2025
Registry last updated
May 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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