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Completed

NCT Number: NCT05742542

The Effects of High vs. Low Time Spent Near VO2max During Two Work-matched High Intensity Interval Training.

Maximal oxygen uptake (VO2max) is used to define cardiorespiratory fitness, which is important to health and sport performance in humans. Although different types of training can improve VO2max, the high intensity interval training is recognized as one of the best ways to do it. Furthermore, it has long been speculated that high intensity interval training that elicits a high time spent near VO2max could be the best way to improve VO2max. However, this theory has not been verified. Thus, the investigators performed a randomized controlled trial with crossover in healthy individuals who underwent two high intensity interval training protocols of two weeks, being a workout with longer and other with shorter time spent near VO2max.

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Key information

Conditions

VO2max Behavior Motor Activity

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of the State of Santa Catarina

Florianópolis, Santa Catarina, 88080-350, Brazil

About this study

Fifteen participants were enrolled in a randomized trial with crossover to perform two weeks of high intensity interval training with high (i.e., five times 2 minutes of work and 1 minute of recovery; T-2min:1min) or low (i.e., ten times 1 minutes of work and 30 seconds of recovery; T-1min:30seg) time spent near VO2max. The work intensity was adjusted at 85% and 87% of power output achieved at the end of incremental test for the first and second week, respectively. Before and after the T-2min:1min and T-1min:30seg, the participants performed tests to determine VO2max, lactate threshold, muscle oxidative capacity, pulmonary oxygen uptake kinetics, power output achieved at the end of incremental test, and power output related to Wingate anaerobic test. The training programs had a washout period of at least one month.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male ≥ 18 years;
  • No known musculoskeletal disorders;
  • Apparently healthy
  • Physically active according to American College of Sports Medicine standards and recommendations (Garber et al., 2011; RIEBE et al., 2015).

Exclusion criteria

  • Taking any medication that could affect aerobic parameters;
  • Smokers;
  • Involved in an aerobic training program at the start of the study.

Treatment and study plan

Exercise training

Other

Two weeks of high intensity interval training with high or low time spent near VO2max.

Primary outcomes

  1. Maximal oxygen uptake

    Time frame: Change at Maximal oxygen uptake after two weeks

    The highest 15 seconds VO2 average determined from rolling averages of 5 seconds samples measured during incremental test or confirmation test of VO2max.

Secondary outcomes

  1. Lactate threshold

    Time frame: Change at Lactate threshold after two weeks

    The work intensity at which blood lactate concentration increased 1 mmol.L-1 above baseline.

  2. Muscle oxidative capacity

    Time frame: Change at Muscle oxidative capacity after two weeks

    Rate recovery of muscle oxygen consumption (k-mV̇O2) of the vastus lateralis, with the k-mV̇O2 indicating muscle oxidative capacity.

  3. Pulmonary oxygen uptake kinetics

    Time frame: Change at Pulmonary oxygen uptake kinetics after two weeks

    The on-transient response for V̇O2 was fitted using a mono-exponential model, which the rate constant (k-pV̇O2) for the kinetics of V̇O2 was calculated as 1/tau (expressed in min-1).

  4. Power output achieved at the end of incremental test

    Time frame: Change at Power output achieved at the end of incremental test after two weeks

    Power output achieved at the end of ramp incremental test (20 W.min-1).

  5. Wingate anaerobic test

    Time frame: Change at Wingate anaerobic test after two weeks

    Peak power, mean power, and minimum power were defined as the highest mechanical power output, the average power sustained throughout the 30-s period, and the power output attained before the end of the test, respectively.

  6. Time spent near VO2max

    Time frame: First to the last day of test or training, an average of 4 weeks

    Time spent at or above 90% or 95% of VO2max.

Other outcomes

  1. Session-rating of perceived exertion

    Time frame: First to the last day of test or training, an average of 4 weeks

    The original 10-point version.

  2. Perceived Recovery Status Scale

    Time frame: First to the last day of test or training, an average of 4 weeks

    The original 10-point version from Laurent et al (2011).

  3. Heart rate

    Time frame: First to the last day of test or training, an average of 4 weeks

    Measured before and during exercise and used to determine 1) the highest heart rate, 2) the time spent near highest heart rate, 3) training impulse, and 4) heart rate variability.

  4. Adipose tissue thickness

    Time frame: Change at Adipose tissue thickness after two weeks

    Adipose tissue thickness measured by a B-mode ultrasound imaging.

  5. Body mass

    Time frame: Change at Body mass after two weeks

    Body mass measured by a digital scale.

Sponsors and collaborators

Lead sponsor

University of the State of Santa Catarina

Other

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Feb 24, 2023
Registry last updated
Feb 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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