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Completed

NCT Number: NCT05525403

The Effects of Fatigue on Exercise-Induced Hypoalgesia During a Dynamic Resistance Exercise

The primary purpose of this study is to compare immediate changes in pain sensitivity (pressure pain threshold) during quiet rest, low fatigue exercise, and high fatigue exercise.

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Key information

Conditions

Healthy

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Central Florida

Orlando, Florida, 32765, United States

About this study

Participants will attend three sessions. Participants will fill out questionnaires, undergo pain sensitivity testing, and be randomly assigned to complete a high and low fatigue exercise on either the second or third session. During the exercise, participants will complete three sets of a single leg knee extension exercise with weight equivalent to 50% of their 1 repetition maximum until they report either a high or low fatigue level. Immediately before and after each set, the research team will examine immediate changes in sensitivity to pressure (pressure pain threshold).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pain-free
  • 18-60 years old
  • Participant can appropriately perform the knee extension exercise (assessed during screening)

Exclusion criteria

  • Non-English speaking
  • Regular use of prescription pain medications
  • Current or history of chronic pain condition
  • Currently taking blood-thinning medication
  • Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions
  • Any contraindication to the application of ice, such as: uncontrolled hypertension (blood pressure over 140/90 mmHg), cold urticaria, cryoglobulinemia, paroxysmal cold hemoglobinuria, circulatory compromise
  • Known presence of cardiovascular, pulmonary, or metabolic disease
  • Current use of tobacco products
  • Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+)
  • Surgery, injury, or fracture to the lower back or lower extremity within the past 6 months

Treatment and study plan

Knee Extension Exercise

Other

Participants will be seated in a Steel Flex machine with weight equal to 50% of their 1 repetition maximum added to the machine. Participants will extend the dominant knee until the assigned fatigue level.

Quiet Rest

Other

Participants will sit quietly for two minutes, three times.

Primary outcomes

  1. Change in Pressure Pain Threshold

    Time frame: Change from baseline immediately after exercise

    A digital pressure algometer will be applied to the quadriceps and upper trapezius for two trials each. Participants are instructed to say "stop" or "pain" so the stimulus can be terminated "when the sensation first transitions from pressure to pain" (pain threshold). Participants will rate the pain experienced during the threshold testing using a 101-point numeric pain rate scale (NPRS) anchored with 0= no pain to 100= the most intense pain sensation imaginable immediately following each testing time.

Secondary outcomes

  1. Temporal Summation

    Time frame: Baseline, pre exercise

    Participants will rate a train of 10 heat pulses using the 101-point numerical pain rating scale

  2. Heat Pain Threshold

    Time frame: Baseline, pre exercise

    A thermode will gradually increase temperature. Participants will state when the sensation first becomes painful.

  3. Conditioned Pain Modulation

    Time frame: Baseline, pre exercise

    Pressure pain threshold after an ice water immersion task will be measured.

  4. International Physical Activity Questionnaire Short Form

    Time frame: Baseline, pre exercise

    This is a self-report measure of physical activity that provides data regarding health-related physical activity.

  5. Pittsburgh Sleep Quality Index

    Time frame: Baseline, pre exercise

    This is a 10-item questionnaire in which individuals respond to statements regarding sleep quality. A higher score indicates a worse sleep quality.

  6. Pain Catastrophizing Scale

    Time frame: Baseline, pre exercise

    This is a 13-item questionnaire in which individuals respond to a statement on a five point scale from 0 to 4. Higher scores indicate higher pain catastrophizing levels.

  7. Fear of Pain Questionnaire 9

    Time frame: Baseline, pre exercise

    This is a 9-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate higher fear of pain.

  8. Pain Anxiety Symptom Scale

    Time frame: Baseline, pre exercise

    This is a 20-item questionnaire in which individuals respond to a statement on a six point scale from 0 to 5. Higher scores indicate higher pain-related anxiety.

  9. Brief Resilience Scale

    Time frame: Baseline, pre exercise

    This is a 6-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate greater resilience.

  10. Preference for and Tolerance of the Intensity of Exercise Questionnaire

    Time frame: Baseline, pre exercise

    This is a 16-item questionnaire in which individuals respond to a statement on a five point scale from 1 to 5. Higher scores indicate lower tolerance for the intensity of exercise.

Other outcomes

  1. 1-repetition maximum testing

    Time frame: Baseline, pre exercise

    The amount of weight that can be lifted for 1 repetition

Sponsors and collaborators

Lead sponsor

University of Central Florida

Other

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Sep 1, 2022
Registry last updated
Apr 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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