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NCT Number: NCT07644663

The Effects of Different Anesthetics on the Brain's Neural Networks

This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively. It intends to explore the macro neural mechanisms underlying anesthetic unresponsiveness, so as to further elucidate the mechanisms by which anesthetics induce loss and recovery of consciousness. In addition, this study will identify neural biomarkers under general anesthesia for monitoring patients' actual intraoperative consciousness status. The findings will facilitate the development of monitoring indicators and devices reflecting intraoperative consciousness during general anesthesia, enabling more accurate assessment of patients' intraoperative consciousness status.

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Key information

Conditions

Electroencephalogram (EEG) Anesthesia

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for elective non-cardiac surgery;
  • American Society of Anesthesiologists (ASA) physical status classification I-II;
  • Aged 18 to 65 years, regardless of gender;
  • Body mass index (BMI) greater than 18 kg/m² and no more than 31 kg/m²;
  • Written informed consent voluntarily signed by the patient or legal authorized representative for participation in this study.

Exclusion criteria

Subjects meeting any one of the following items will be excluded from this study:

  • Presence of severe cardiovascular diseases or hepatic and renal insufficiency;
  • Hearing impairment;
  • History of psychiatric disorders or communication disorders;
  • Anticipated difficult airway;
  • Pregnant or lactating women;
  • History of allergic reaction or contraindication to any of the three anesthetic drugs used in this trial;
  • Participation in other clinical trials within the past 3 months.

Treatment and study plan

Propofol

Drug

All patients in this arm receive Propofol at a concentration of 10 mg/mL, administered via infusion at a dose of 1 mg/kg and completed within 5 minutes.

Dexmeditomidine

Drug

All subjects in this arm receive Dexmedetomidine with a prepared concentration of 10 μg/mL. A loading dose of 1.0 μg/kg is administered by infusion and completed within 10 minutes.

Esketamine

Drug

All subjects in this arm are given Esketamine at a prepared concentration of 5 mg/mL, infused at a dose of 0.5 mg/kg and completed within 10 minutes.

Primary outcomes

  1. Permutation cross mutual information (PCMI) and PCMI-based brain networks

    Time frame: From baseline (awake) through loss of responsiveness to recovery of responsiveness

    EEG power spectrum [broadband (0.1-45 Hz) and sub-band frequencies] assessed by high-density EEG

  2. EEG functional connectivity

    Time frame: From baseline (awake) through loss of responsiveness to recovery of responsiveness

    EEG functional connectivity assessed by high-density EEG

Secondary outcomes

  1. heart rate

    Time frame: Perioperative

  2. Blood pressure

    Time frame: Perioperative

  3. Oxygen Saturation

    Time frame: Perioperative

  4. Time to loss of responsiveness after study drug initiation

    Time frame: From start of study drug infusion until loss of responsiveness

Study contacts

Contact information is provided by the study sponsor or research team.

Xiaoge Liu

CONTACT

[email protected]

021-64175590

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Propofol, Dexmedetomidine, and Esketamine-Induced Unresponsive States: Alterations in Information Integration and Brain Networks

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 12, 2026
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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