The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis

Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality. Most dietary guidelines for CKD focus on limiting protein intake (nitrogen) and high phosphorus-containing foods. However, increasing dietary fiber has been proposed to increase fecal nitrogen excretion which may ameliorate the progress of CKD. We therefore plan to conduct a systematic review and meta-analysis on clinical trials to assess the effect of fiber on urea and creatinine as classical markers of a state of uremia in individuals with CKD. We hypothesize that increasing fiber intakes will improve urea and creatinine levels in individuals with CKD.

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Key information

Conditions

Chronic Kidney Disease Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Dietary trials in humans
Randomized treatment allocation
Suitable control (low fiber)
viable endpoint data

Exclusion criteria

Non-human studies
Nonrandomized treatment allocation
Lack of a suitable control (high protein)
no viable endpoint data

Treatment and study plan

Primary outcomes

Creatinine

Time frame: 1.5 years
urea

Time frame: 1.5 years

Secondary outcomes

Phosphorus

Time frame: 1.5 years

Sponsors and collaborators

Lead sponsor

Unity Health Toronto

Other

Registry information

Official study title

The Effects of Dietary Fiber on Uremic Retention Solutes in CKD: A Systematic Review and Meta-analysis

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: May 3, 2013
Registry last updated: Nov 21, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed