The Effects of Dexmedetomidine and Tracheal Intubation on Heart Rate Variability and QTc Interval

The purpose of this study is to investigate effect of dexmedetomidine and tracheal intubation on heart rate variability and QTc interval.

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Key information

Conditions

Anesthesia, General

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Severance hospital

Seoul, 120-752, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patient who are regarded as ASA class I
age 20 to 60
patient scheduled for Intubation for surgery

Exclusion criteria

QTc interval > 440 ms
arrythmia
Patient who is taking a medicine which effects QTc interval
HTN
DM
renal disease
hepatic disease
pregnant
illiterate

Treatment and study plan

0.5 mcg/kg IV infusion for 10 min, 1.0 mcg/kg IV infusion for 10 min

Drug

ECG monitoring for evaluation of QTc interval

Primary outcomes

Change of QTc interval

Time frame: T1 (at rest), T2 (5 min after dexmedetomidine infusion), T3 (just before intubation), T4(1 min after intubation), T5(2 min after intubation), T6(3min after intubation)

T1- baseline, T2- to evaluate the effect of dexmedetomidine on QTc interval, T3- to evaluate QTc interval just before intubation, T4,5,6 - to evaluate QTc interval after intubation

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2013
First posted: Apr 25, 2012
Registry last updated: Feb 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed