Skip to main content
OpenTrials
Completed

NCT Number: NCT02531451

The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults

In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Skeletal Muscle Mass Regulation

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Karolinska Institutet

Stockholm, 14186, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Considered healthy
  • Moderately trained
  • 18-35 yrs

Exclusion criteria

  • Cardiovascular disease
  • Impaired kidney or liver function
  • Lower limb injury
  • Pregnancy
  • Ulcer or gastrointestinal upsets
  • Previous reactions to use of NSAID

Treatment and study plan

Ibuprofen

Drug

acetylsalicylic acid

Drug

Primary outcomes

  1. Change in Quadriceps muscle volume

    Time frame: Baseline and after 8 weeks training

    Measured through MRI

Secondary outcomes

  1. Change in muscle gene expression

    Time frame: Baseline, 4 weeks and after 8 weeks training

    Through quantitative PCR and microarray

  2. Change in muscle protein expression

    Time frame: Baseline, 4 weeks and after 8 weeks training

    Through Western Blots

  3. Change in Quadriceps muscle strength

    Time frame: Baseline and after 8 weeks training

    Measured in strength dynamometers

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Registry information

Official study title

The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise

Acronym: NSAID2015

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Aug 24, 2015
Registry last updated
Jun 28, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.