The Effects of Coffee Main Constituents (Caffeine and Chlorogenic Acid) Supplementation on Inflammatory, Metabolic Factors, Hepatic Steatosis and Fibrosis in None- Alcoholic Fatty Liver Patients With Type 2 Diabetes

Inclusion criteria

• Patient diagnosed with type 2 diabetes based on American Diabetes Association (ADA) definition or who only take oral antidiabetic drug.
• CAPscore >263

Exclusion criteria

• Criteria:

• Taking any kind of antibiotics two weeks before recruitment;
• History of alcohol consumption ;
• pregnancy or lactation;
• Professional athletes;
• Other liver disease (viral/etc);
• High dose synthetic estrogens, methotrexate , amiodarone, steroids, chloroquine, immunosuppressive drugs;
• A history of Cardiovascular disease;
• Renal disease, Celiac disease, Cirrhosis;
• History of Upper Gastrointestinal surgery ;
• A history of hypothyroidism or Cushing's syndrome;
• History of drug dependence;
• Body mass index (BMI) ≥35 kg/m2;
• A restrictive diet or weight change ≥ 5 kg during the 3 months prior to study;
• Any change in treatment with oral hypoglycemic; anti hypertensive and antilipid agents during the study;
• Use of weight loss medications