The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients

To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of diuretics) in cirrhotics with increased sympathetic nervous system. Secondary objectives were to study neuro-hormonal,hemodynamic effects and side effects of clonidine and diuretics.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Ascitic Cirrhosis Hyperactivation of Sympathetic Nervous System

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

ISPPC CHU de Charleroi

Charleroi, 6000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cirrhotic patients with ascites
Plasma norepinephrine level > 300 pg/mL (normal value: 185 - 275 pg/mL)

Exclusion criteria

Serum bilirubin concentration above 4.5 mg/dL
Prothrombin time below 40%
Platelet count below 40 X 10¨9/liter
Serum creatinine concentration above 2 mg/dL
Gastro-intestinal hemorrhage
Alcoholic hepatitis
Diabetes mellitus,
Hepatocellular carcinoma
Respiratory or cardiac failures
Hepatic encephalopathy
Bacterial infection

Treatment and study plan

Clonidine

Drug

Sponsors and collaborators

Lead sponsor

CHU de Charleroi

Other

Registry information

Official study title

The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients With Ascites and Activation of Sympathetic Nervous System: a Randomized Double-Blind Placebo Controlled Study.

Important dates

Study start: 2000
First posted: Jul 25, 2006
Registry last updated: Dec 4, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.