Skip to main content
OpenTrials
Completed

NCT Number: NCT02499107

The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children

This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children. Healthy boys and girls, aged between 11 - 13 years old, will be involved in this study.

Completed

Looking for future studies?

Notify Me

Key information

Age range

11 year–13 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutritional Sciences, FitzGerald Building

Toronto, Ontario, M5S 3E2, Canada

About this study

The prevalence of childhood obesity and overweight has become a major health concern worldwide. Prevention of overweight and obesity in children is a high priority because they are at high risk of becoming obese adults and obesity is predictive of the development of coronary heart disease, hypertension and diabetes. Thus, there is a need for food-based solutions to increase satiety and subsequently reduce energy intake.

Over the past 40 years, the consumption of potatoes has decreased by 41% which may be a consequence of movements aimed at decreasing serving sizes, or the outright banning, of potato foods from cafeterias and quick service restaurants such as French fries due to the observational studies showing they are linked with increased risk of obesity. Alternate energy dense starches such as rice and pasta have increased in consumption as a result for meal accompaniments with no discernible decrease in the upward trajectory of the number of overweight and obese individuals. These recent trends may be a consequence of individuals ignoring vital information such as the substantial nutrient content as well as the overall balance and low energy density to nutrient density ratio of the potato in addition to other beneficial components.

Compounding this, research has also indicated that the GI of potatoes is high relative to other starches, in spite of recent evidence suggesting a high variability in these measurements or little consideration taken for the preparation method of the potato (potato chips vs. baked potato, for example). Additionally, potatoes are commonly consumed with other foods which in turn often significantly lower the GI of the meal when compared to consumption of the potato alone. For example, Estima potatoes ingested with 62 g of cheddar cheese reduced the GI from 93 to 39 and mashed potatoes served with oil, chicken breast and salad (representing a meal) reduced the GI of the potato from 108 to 54. The GI is based on the consumption of a fixed amount of available carbohydrate, which may not be representative of the glycaemic effect of the amount of carbohydrate usually consumed in a serving of a food within a meal, such as the case with potatoes.

We have extensive experience in conducting experimental studies especially with children. Previously in our laboratory, we investigated and published numerous studies focused on assessing food intake (FI) regulation and appetite in children aged 9 to 13 years.

Thus, the purpose of the current study is to determine effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children (aged 11 to 13 years) over a 2 hour period.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • boys and girls
  • age 11 to 13 years old
  • healthy
  • BMI-for-age percentile 15% to 85%

Exclusion criteria

  • taking any medications,
  • Parental report of children with major disease,
  • behavioral or emotional difficulties,
  • children who have a food allergy,
  • children follow a therapeutic diet, or do not habitually eat breakfast

Treatment and study plan

Rice treatment

Dietary Supplement

All arms are given to all participants, in a randomized (cross over) order

Pasta treatment

Dietary Supplement

Boiled and mashed potato treatment

Dietary Supplement

Baked french fries treatment

Dietary Supplement

Fried french fries treatment

Dietary Supplement

Primary outcomes

  1. Food Intake

    Time frame: Food intake will be measured at 30 min after ad libitum carbohydrate intake

    Food intake (kCal) will be assessed 30 min after consumption of the ad libitum treatments of either rice, pasta, boiled and mashed potatoes, baked french fries or fried french fries.

Secondary outcomes

  1. blood glucose

    Time frame: blood glucose will be measured at 0, 30, 45, 60, 75, 90 and 120 min - during the 2 hours study period.

    Blood glucose (mmol/L) will be measured using finger prick capillary blood samples

  2. Plasma Insulin hormone

    Time frame: Insulin will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.

    Plasma Insulin hormone will be measured using intra-venous blood sample

  3. Plasma Glucogan like peptide (GLP-1) hormone

    Time frame: GLP-1 will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.

    Plasma GLP-1 hormone will be measured using intra-venous blood sample

  4. Plasma ghrelin hormone

    Time frame: Active ghrelin hormone will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.

    Plasma ghrelin hormone will be measured using intra-venous blood sample

  5. Peptide YY (PYY) hormone

    Time frame: PYY hormone will be measured at 0, 30, 60 and 120 min - during the 2 hours study period.

    Plasma PYY hormone will be measured using intra-venous blood sample

  6. subjective appetite

    Time frame: Subjective appetite will be measured at 0, 30, 45, 60, 75, 90 and 120 min - during the 2 hours study period.

    Subjective appetite will be measured by using visual analouge scales

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Registry information

Official study title

The Effects of Potatoes and Other Carbohydrate Side Dishes Consumed With Meat on Food Intake, Glycaemia and Satiety Response in Children

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Jul 15, 2015
Registry last updated
May 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.