Liao Lab at UCSF
San Francisco, California, 94115, United States
Location status: Recruiting
Location contact
Amélie Spangenberg, Psoriasis Clinical Research Fellow, MBBS
CONTACT
Wilson Liao, MD
PRINCIPAL_INVESTIGATOR
Recruiting
NCT Number: NCT07390487
The Effects of Audio-Based Therapy on Anxiety in Psoriasis
Anxiety in psoriasis is associated with impaired quality of life, and the prevalence of anxiety symptoms in psoriatic populations is approximately 34% and anxiety disorders up to 16%. Many experts recommend routine screening, referral, and interventions for anxiety in psoriasis; however, many barriers inhibit access to mental health resources and proper management. To our knowledge, there is a lack of easily accessible interventions that manage anxiety. Audio-based therapy offers convenient and effective interventions that show reduced anxiety in published, randomized studies and is a promising management for psoriasis patients. This study will evaluate the effects of audio therapy in patients with psoriasis and measure changes in overall symptoms.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age ≥18 years
- Self-reported dermatologist-diagnosed psoriasis
- GAD 2-Item Score ≥1 at screening
- Ability to consent and complete pre- and post-intervention surveys.
- Internet access and the ability to use a computer/smartphone with headphones for a single 23-30 minute session at home.
Exclusion criteria
- Severe hearing impairment precluding headphone listening
- Any condition requiring strict sound avoidance (such as seizure/epilepsy, major head trauma, severe sound-triggered migraine) that would make participation unsafe.
- Other diagnoses that in the investigator's judgment preclude safe participation or interfere with anxiety or psoriasis evaluation.
Treatment and study plan
Music Therapy
BehavioralParticipants listen to the iso-principle music with added auditory beat stimulation playlist for 23-30 minutes.
Other names: Music therapy and auditory beat stimulation (ABS), Music, Complementary Therapy, Complementary Therapies, Acoustic Stimulation
Pink Noise
BehavioralParticipants listen to the pink noise playlist for 23-30 minutes.
Primary outcomes
-
Anxiety: State Trait Inventory for Cognitive and Somatic Anxiety (STICSA)
Time frame: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.
The STICSA has good reliability and validity as a measure of state and trait cognitive and somatic anxiety. In this study, the post-intervention anxiety score is subtracted from the pre-intervention anxiety score, giving a measure of anxiety reduction. Greater anxiety reduction scores would indicate a better anxiety outcome.
Secondary outcomes
-
Mood: Positive and Negative Affect Scale (PANAS)
Time frame: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.
The PANAS has demonstrated good reliability and validity, and has been widely used in numerous studies to assess mood. In this study, the post-intervention PANAS scores are subtracted from the pre-intervention PANAS scores, giving a measure of positive and negative mood changes. The scale generates two scores: 1) Positive affect (higher score indicates better mood outcome) and 2) Negative affect (higher score indicates worse mood outcome).
-
Itch: Itch Numeric Rating Score (INRS)
Time frame: From the pre-intervention survey to the post-intervention survey, approximately 30 minutes.
The INRS has good reliability and validity as a measure of 24-hour itch severity, though validity testing over more acute intervals remains limited. In this study, the post-intervention itch score is subtracted from the pre-intervention itch score, giving a measure of itch reduction. Greater itch reduction scores may indicate a better itch outcome.
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
University of California, San Francisco
Other
Registry information
Acronym: PsOUND-PSO
Important dates
- Study start
- 2026
- Primary completion
- 2027
- Study completion
- 2027
- First posted
- Feb 5, 2026
- Registry last updated
- Jul 23, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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