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Completed

NCT Number: NCT03228446

The Effects of Attentional Filter Training on Working Memory

The investigators are interested in how attentional filter training/ distractor inhibition training could influence cognitive functions like working memory, executive control, problem solving, decision making and attentional control.

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Key information

Conditions

Cognitive Decline Age-related Cognitive Decline Cognition Disorders Cognitive Dysfunction Healthy Mental Disorders Neurocognitive Disorders

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

DZNE

Magdeburg, Saxony-Anhalt, 39120, Germany

About this study

Two different computer based trainings were applied: an attentional filter training and a working memory training.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right-hander
  • aged between 18-30 or 60-80years

Exclusion criteria

  • severe visual impairments (e.g. dyschromatopsia, very low vision)
  • diseases or medication that might impair test performance
  • Montreal Cognitive Assessment Score (MoCA) < 26 points

Treatment and study plan

filter training

Behavioral

one-week filter training on the computer: computerized visual change detection experiment (selective attention )

memory training

Behavioral

one-week storage training on the computer: computerized visual change detection experiment (memory storage)

no training (control)

Other

no training applied

Primary outcomes

  1. Improvements in test performance

    Time frame: 45min pre / post

    Working memory and filtering performance (in %), effects of distractor interference and reaction times for trials with and without distractors with 4, 5 & 6 targets

Secondary outcomes

  1. Rey Complex Figure Test

    Time frame: 30min pre / post

    Copying complex figures and reproduce it from memory

  2. Memory from TAP (Test battery of Attentional Performance)

    Time frame: 45min pre / post

    Working Memory (n-back)

  3. Attention from TAP (Test battery of Attentional Performance)

    Time frame: 45min pre / post

    divided attention, Go-NoGo, Flexibility, Incompatibility, Visual scanning

  4. Performance in repeating numbers

    Time frame: 10min pre / post

    Repeating numbers in forward & backward conditions

  5. Subtest from CANTAB (Cambridge Neuropsychological Test Automated Battery)

    Time frame: 10min pre / post

    Spatial Span Test

  6. Iowa Gambling Task

    Time frame: 5min on each training day (1-5)

    Decision making

  7. Daily Questionnaires

    Time frame: 2 min on each training day (1-5)

    subjective performance in the training paradigm

  8. Daily Questionnaires

    Time frame: 2min on each training day (1-5)

    Assessing external circumstances of daily influences

  9. Memory performance without distractors among different setsizes

    Time frame: 45min pre / post

    Working memory performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors

  10. Memory performance with distractors among different setsizes

    Time frame: 45min pre / post

    Working memory performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors

  11. Filtering performance without distractors among different setsizes

    Time frame: 45min pre / post

    Filtering performance (in %) for trials with 4, 5 & 6 targets and averaged performance for all conditions without distractors

  12. Filtering performance with distractors among different setsizes

    Time frame: 45min pre / post

    Filtering performance (in %) for trials with 4, 5 & 6 targets and distractors and averaged performance for all conditions with distractors

  13. Reaction times

    Time frame: 45min pre / post

    Reaction times in each condition

  14. Values of distractor inhibition

    Time frame: 45min pre / post

    Distractor inhibition (DIIN) = Mean of conditions without distractors - Mean of conditions with distractors

Sponsors and collaborators

Lead sponsor

German Center for Neurodegenerative Diseases (DZNE)

Other

Collaborators

  • German Research Foundation

Registry information

Official study title

Improving Cognitive Functions by Training Distractor Inhibition (DIIN) in Younger and Older Healthy Adults

Acronym: DIIN

Important dates

Study start
2012
Primary completion
2018
Study completion
2019
First posted
Jul 25, 2017
Registry last updated
Feb 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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