The Effects of Altering Physical Activity on Cardiometabolic Health

The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

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Key information

Conditions

Insulin Resistance Behavior Glucose Metabolism Disorders Hyperinsulinism Metabolic Diseases Motor Activity Nutritional and Metabolic Diseases

Age range

19 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Missouri

Columbia, Missouri, 65211, United States

About this study

Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to <5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI: less than 30 kg/m2
Physically active: exercise greater than 60mins per week

Exclusion criteria

smoking
type 2 diabetes
Underlying conditions that limit ability to exercise safely
Recent weight gain or loss(> 5% of body weight in 3 months)
Recent (< 3 mo) changes in medication use or dose
Pregnancy

Treatment and study plan

Exercise

Behavioral

short period of inactivity (5 days) followed by a return to physical activity (1 day)

Primary outcomes

Effects of Physical Inactivity on Post Prandial Blood Flow

Time frame: 10 days

There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity.

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Registry information

Official study title

The Effects of Altering Physical Activity on Endothelial Function, Glycemic Control, and the Blood Flow Response to an Oral Glucose Tolerance Test.

Acronym: PIA

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: Jun 17, 2013
Registry last updated: Feb 8, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed