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Completed

NCT Number: NCT02514564

The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.

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Key information

Conditions

Cardiovascular Diseases

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Instituto Nacional de Cardiologia

Rio de Janeiro, 21040-900, Brazil

About this study

Aerobic exercise training is well known to improve endothelium dependent vasodilatation in the microcirculation. However, the impact of exercise frequency on this response in patients with coronary artery disease remains unclear.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • sedentarism for at least 6 months;
  • clinical diagnosis for coronary artery disease (occurrence of any acute coronary syndrome, including ST elevation or non-ST elevation myocardial infarction or unstable angina or by the diagnosis of obstructive coronary artery disease on coronary angiography in patients with stable angina).

Exclusion criteria

  • nephropathies;
  • decompensated cardiovascular diseases;
  • liver diseases.

Treatment and study plan

Exercise

Behavioral

Patients included in the study will be enrolled in a cardiac rehabilitation program, in an independent manner of the study protocols.

Sedentarism

Behavioral

Participants will remain sedentary.

Primary outcomes

  1. Changes in Skin microvascular blood flow

    Time frame: Change from baseline in skin microvascular blood flow at 6 months

    Measured through a Laser Speckle Contrast Imaging equipment

Secondary outcomes

  1. Change in peak oxygen consumption

    Time frame: Change from baseline in peak oxygen consumption at 6 months

    Measured at a maximal graded exercise test

  2. Change in weight

    Time frame: Change from baseline in weight at 6 months

    Measured with a calibrated digital scale

Sponsors and collaborators

Lead sponsor

Instituto Nacional de Cardiologia de Laranjeiras

Other

Registry information

Official study title

The Effects of Aerobic Exercise Training in Patients With Cardiovascular Diseases Related to Microvascular Endothelium Function, Angiogenesis, Oxidative Stress and Aerobic Capacity

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Aug 3, 2015
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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