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OpenTrials
Completed

NCT Number: NCT03045588

The Effects of a Train High, Sleep Low Strategy

The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

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Key information

Conditions

Cycling Performance Muscular Adaptations Substrate Utilization

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-45 years
  • VO2-max>55 ml/kg/min
  • No smokers
  • Training 6 hours per week (cycling)
  • Training experience for more than 3 years.

Exclusion criteria

  • Less than 2 g carbohydrate/kg/day

Treatment and study plan

Combined exercise and diet intervention

Other

Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.

Primary outcomes

  1. Time trial performance measured in Watts

    Time frame: Change from Baseline and after 4 weeks of training

    30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.

Secondary outcomes

  1. Protein expression in skeletal muscle tissue

    Time frame: Baseline and after 4 weeks of training

    Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique

  2. The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute

    Time frame: Baseline and after 4 weeks of training

    Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry.

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Team Denmark

Registry information

Official study title

The Effects of a Train High, Sleep Low Strategy on Performance, Substrate Utilization and Muscular Adaptations in Moderately Trained Cyclists

Important dates

Study start
2016
Primary completion
2016
Study completion
2018
First posted
Feb 7, 2017
Registry last updated
Oct 24, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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