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OpenTrials
Completed

NCT Number: NCT00985933

The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers

The purpose of this study is to assess if ketamine will induce, in healthy volunteers, impairment of working memory and if the drug AZD8529 will block the effects of ketamine on working memory as assessed by functional magnetic resonance imaging (fMRI).

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Key information

Conditions

Healthy Memory Disorders Memory Impairment Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Research Site

New Haven, Connecticut, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Right handed
  • 12th grade education or equivalent
  • Able to read and write English as primary language

Exclusion criteria

  • History of head injury
  • Substance abuse or dependence
  • History of claustrophobia

Treatment and study plan

AZD8529

Drug

6 capsules by mouth 1 time 12 to 24 prior to assessments

Placebo to match AZD8529

Drug

6 capsules by mouth 1 time 12 to 24 hours prior to assessments

Primary outcomes

  1. fMRI

    Time frame: 3

  2. Ketamine Infusion

    Time frame: 3

Secondary outcomes

  1. Clinician Administered Dissociative States Scale (CADSS)

  2. Positive and Negative Syndrome Scale (PANSS)

  3. Laboratory assessment: electrocardiogram (ECG), physical exam, vital signs, collection of adverse events

Sponsors and collaborators

Lead sponsor

AstraZeneca

Industry

Registry information

Official study title

A Single Center, Double-Blind, Randomized, Double Dummy, Placebo-Controlled, Three-Period Crossover Study to Assess the Effects of a mGluR2/3 Positive Allosteric Modulator [AZD8529] Upon Ketamine-Induced Cortical Stimulation and Impairment of Working-Memory Related Activation of the Prefrontal Cortex

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Sep 29, 2009
Registry last updated
May 4, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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