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Completed

NCT Number: NCT04851821

The Effectiveness of Phytotherapy in SARS-COV2(COVID-19)

Quercetin is one of the flavonoids. Quercetin as well as rutin are recognized to be among the most active of the flavonoids. It is to quercetin that several medicinal plants, including ginkgo and St. John's Wort, owe part of their therapeutic effects. Often combined with vitamin C in supplements, it improves absorption by the body and delays its elimination.

Quercetin is extracted from a variety of plant sources, including the onion peel and seeds and pods of Dimorphandra mollis, a tree in the legume family native to South America.

At present, there is no scientific data to demonstrate the effectiveness of herbal medicine, regardless of the plant, to prevent or treat COVID-19. On the other hand, some plant-based food supplements have anti-inflammatory or immunomodulatory properties that may disrupt inflammatory defense mechanisms useful in fighting infections, and in particular against COVID-19.

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Key information

Conditions

a Randomized Double-blind Study PHYTOTHERAPIE Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Riadh Boukef

Sahloul, Sousse Governorate, Tunisia

About this study

Type of study: a randomized, double-blind study using the Quercetine in the treatment of patients with SARS COV2 (covid-19) Quercetin is extracted from a variety of plant sources, including the onion peel and the seeds and pods of Dimorphandra mollis, a legume tree native to South America.

Although we are far from knowing everything about quercetin, its antioxidant, anti-inflammatory, and antihistamine (antiallergic) properties have been observed in numerous in vitro and animal studies.

History on quercetin In 1937, Albert Szent-Gyorgyi received a Nobel Prize for discovering vitamin C and flavonoids, as well as for exploring their biochemical properties. Originally, he gave the flavonoids the name "vitamin P" because of their effectiveness in reducing the permeability of blood vessels. This name was abandoned when it was realized that these substances were not really vitamins.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients attending the emergency department for influenza-like illness.
  • Being over 18 years old

Exclusion criteria

  • Any patient requiring admission
  • Non-consenting patients

Treatment and study plan

Quercetin

Drug

Each patient included, after signing the consent, will have a treatment for ten days: one tablet times three per day 30 minutes before the meal.

Other names: PLACEBO

Primary outcomes

  1. Number of patients

    Time frame: 10 DAYS

    Number of patients attending the emergency room

Secondary outcomes

  1. disappearance of symptoms

    Time frame: 10 days

    Date of disappearance of symptoms present on admission

  2. adverse reaction

    Time frame: 10 days

    Presence of an adverse reaction due to the administration of the treatment

Sponsors and collaborators

Lead sponsor

Hôpital Universitaire Sahloul

Other

Registry information

Official study title

The Effectiveness of Phytotherapy in the Treatment of SARS-COV2 (COVID-19)

Acronym: Quercetix

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Apr 20, 2021
Registry last updated
Jan 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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