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Completed

NCT Number: NCT01930500

The Effectiveness of Neuropsychological Rehabilitation in Young Dyslexic Adults

The purpose of this study is to determine whether individual and/ group based neuropsychological rehabilitation focused on psychoeducation and teaching compensatory strategies has positive effects on the psychosocial wellbeing and perceived cognitive deficits in dyslexic young adults. The hypothesis is that both individual and group based neuropsychological rehabilitation show positive effects on the psychosocial wellbeing and perceived cognitive deficits. Another purpose of this study is to evaluate weather individual and group based neuropsychological rehabilitation have different kind of effects on the wellbeing of the participants and weather either one of the rehabilitation formats is more effective than the other.

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Key information

Conditions

Dyslexia Communication Disorders Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Specific Learning Disorder

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rehabilitation Foundation

Helsinki, Malminkartano, 00410, Finland

About this study

Background: Untreated dyslexia causes problems for individuals in studies, work and employment. High quality research on the best and most cost-effective rehabilitation methods is needed.

Objective: To study whether neuropsychological rehabilitation improves the psychosocial wellbeing and perceived cognitive deficits in dyslexic young adults and to evaluate potential differences between individual and group based neuropsychological rehabilitation.

Methods: Altogether 120 young adults diagnosed with dyslexia are randomized either to one of the intervention groups (individual neuropsychological rehabilitation / group neuropsychological rehabilitation) or to a control group which will receive either one of the interventions after a 5 month waiting period. All the study subjects are assessed with a short neuropsychological test battery as well as self-rating questionnaires evaluating mood, QoL, perceived cognitive deficits, and the impact of the learning disability at baseline, after five months (immediately after interventions or control period) and after 10 months. After 20 months a shorter follow-up using only self-ratings will be done via mail. Subjects in the intervention groups are offered neuropsychological rehabilitation in 12 sessions conducted once a week or once in two weeks during five months. Subjects in the control group do not receive any intervention for the first five months.

Results: The effects of interventions on psychosocial wellbeing and perceived cognitive deficits are evaluated using appropriate statistical procedures and comparing the differences between the interventions groups and the control group.

The present status: All the interventions are completed, follow-up data is still beeing collected

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical diagnosis of dyslexia
  • age 18-35
  • problems in studies, work or employment relating to dyslexia
  • subjective and objective need for rehabilitation
  • the native language is Finnish

Exclusion criteria

  • other neurological condition than dyslexia
  • other learning disabilities than dyslexia
  • overall weak cognitive capacity
  • psychiatric diagnosis
  • severe depression
  • alcohol or drug abuse
  • neuropsychological rehabilitation received at the age of 16 or later

Treatment and study plan

Individual neuropsychological rehabilitation

Behavioral

Psychoeducation, teaching compensatory strategies and offering psychological support to better cope with dyslexia

Group based neuropsychological rehabilitation

Behavioral

Psychoeducation, teaching compensatory strategies and offering psychological support and peer support to better cope with dyslexia

Primary outcomes

  1. Subjective cognitive performance

    Time frame: 5 months

    The effects of rehabilitation on subjective cognitive performance: Everyday Memory Questionnaire (EMQ)

  2. Subjective reading related performance

    Time frame: 5 months

    Effects of rehabilitation on subjective reading related performance: Adult Reading History Questionnaire (ARHQ) modified

Secondary outcomes

  1. Verbal fluency and executive control

    Time frame: 5 months

    These cognitive skills are measured using verbal fluency with category switching, Delis-Kaplan Executive Function System; D-KEFS. The score is the total number of correct words generated by the participant within the one-minute time-limit. The range for points is from 0 to as many words as can be generated by the rules within one minute. More points equals a better result.

  2. Goal achievement

    Time frame: 5 months

    Goal achievement is measures using Goal Attainment Scaling (GAS). The attained goals set at the beginning of the intervention and measured on a scale from -2 to +2 at the end of the intervention. The score is based on a discussion with the therapist and the participant. A score below zero means that the set goal has not been reached. A score of 0 means that the goal has been reached and scores above 0 mean that the goal was reached over expectations.

  3. Quality of life: QOLIBRI-OS

    Time frame: 5 months

    The effects of rehabilitation on quality of life are measured using the Quality of Life after Brain Injury Overall Scale (QOLIBRI-OS). The score ranges from 6-30. More points equals a better quality of life.

  4. Mood

    Time frame: 5 months

    The effects of rehabilitation on mood are measured using Profile of Mood States (POMS). The Finnish version contains 38 questions and the total score ranges from 0 to 152. Less points means a better situation for mood.

  5. Social and cognitive behavioral strategies

    Time frame: 5 months

    Strategy and Attribution Questionnaire (SAQ) bref consists of 20 questions using a 7-point-scale (from 1 = "strongly disagree" to 7 = "strongly agree") to assess social and cognitive behavioral strategies.

  6. Processing speed and attention

    Time frame: 5 months

    These cognitive skills are measured using Symbol Digit Modalities test. The score ranges from 0 to 110. More points equals a better result.

  7. Verbal learning

    Time frame: 5 months

    Verbal learning is measured using Word lists subtest (Wechsler Memory Test-III, WMS-III). The total score is between 0 - 48. More points equals a better result.

  8. Reading comprehension

    Time frame: 5 months

    Reading comprehension is measured using V3, a part of a Finnish Ability Test Battery, "Kykytestistö AVO-9". The score ranges fron 0 to 20. More points equals a better result.

  9. Visual fluency and executive control

    Time frame: 5 months

    These cognitive skills are measured using design fluency, Delis-Kaplan Executive Function System; D-KEFS. The score is the total number of correct drawings produced within a minute added togehter from three different one-minute long sessions with different rules. The range for points is from 0 to as many drawings as can be generated by the rules within the three one-minute sessions. More points equals a better result.

  10. Working memory

    Time frame: 5 months

    Working memory is assesed using Digit span sequencing (Wechsler Adult Intelligence Scale - Fourth Edition, WAIS-IV). The total score is between 0 - 16. More points equals better result.

Sponsors and collaborators

Lead sponsor

Rehabilitation Foundation, Finland

Other

Collaborators

  • Helsinki University Central Hospital
  • Social Insurance Institution, Finland

Registry information

Official study title

The Effectiveness of Neuropsychological Rehabilitation in Young Dyslexic Adults - a Single Blind, Randomized, Controlled Study

Important dates

Study start
2012
Primary completion
2015
Study completion
2017
First posted
Aug 29, 2013
Registry last updated
Apr 12, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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