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Completed

NCT Number: NCT03732053

The Effectiveness of Global Postural Reeducation on Alzheimer Disease Patients

This research study is developed on an experimental design with randomized controlled intervention were participated 135 subjects with AD including 45 of the control group. It lasted 6 months with pre-post tests (T0-T1) executed before and after six months of treatment. By having in focus the evaluation of GPR therapy effects on cognitive, proprioceptive, depressive, autonomy, gait and life quality of the above mentioned subjects.

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Key information

Conditions

Alzheimer's Type Dementia Cognition Disorders Cognitive Decline Cognitive Dysfunction Mental Disorders Neurocognitive Disorders Postural; Strain Sprains and Strains Wounds and Injuries

Age range

40 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

In order to assess the cognitive abilities of the patients a cognitive test was administered which acts through a scale concerning depression and mood evaluation as well as a questionnaire was developed aiming to evaluate the examined subjects' functional abilities: Mini Mental State Examination (MMSE), Quality of Life in Alzheimer Disease (QoL-AD), geriatric Depression Scale (GDS), Barthel Index (BI), Neuropsychiatric Inventory (NPI), Tinetti Scale (TS).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of Alzheimer's Disease
  • Older than 40 years of age
  • Male and female
  • Intellectual disability
  • Cognitive impairment
  • Able to do daily activities on his own
  • No presence of any other neurological and psychological disease
  • No presence of brain tumors

Exclusion criteria

  • No presence of Alzheimer's Disease
  • Under 40 years old
  • Presence of brain tumors
  • Neurological patients
  • Presence of psychiatric disease
  • Depression symptoms
  • Presence of neuromuscular disease
  • Ictus
  • Aggressive patients

Treatment and study plan

GPR Intervention Research group

Other

The research intervention consisted in the reappointment of three GPR therapeutic postures.

Primary outcomes

  1. Cognitive Abilities Measurement

    Time frame: Change from baseline cognitive evaluation at 6'th month

    The therapeutist provides the Mini Mental State Examination (MMSE) scale records. The evaluation consits in a 0-30 points-scale. Lower scores imply the severity of dementia.

Secondary outcomes

  1. Quality of Life in Alzheimer's disease (QoL-AD) Questionnaire

    Time frame: Change from baseline cognitive evaluation at 6'th month

    The therapeutist measures in the begining and in the end of the study the quality of life in patients with Alzheimer's disease (QoL-AD). This questionnaire consists in 13 elements referring to the perception that patients have concerning various aspects of their life: mood, health, cognition, environment and functional capacity. The range of scores is 13-52, were higher scores indicate a better life quality.

  2. Geriatric Depression Scale (GDS) Questionnaire

    Time frame: Change from baseline cognitive evaluation at 6'th month

    The version of 15 articles was used, which given its length can be validly and reliably resolved by patients themselves in the quality of a self-report questionnaire aiming to investigate the possible presence of depressive symptoms.

  3. Barthel Index (BI)

    Time frame: Change from baseline cognitive evaluation at 6'th month

    This scale is used by therapist to measure the performance in the basic activities of daily life of AD patients. The maximum score used is 100 points and refers to the patient's independence in all basic daily living activities.

  4. Neuropsychiatric Inventory (NPI)

    Time frame: Change from baseline cognitive evaluation at 6'th month

    This test includes 12 symptoms scored according to the phenomenon severity and frequency. It is a helpful instrument for the therapist because of specifically designed for the assessment of psycho-behavioral disorders in individuals with cognitive impairment.

  5. Tinetti Scale (TS)

    Time frame: Change from baseline cognitive evaluation at 6'th month

    The therapist used the equilibrium sub-scale, which consists in 7 elements and has a score between 0 and 13. Highest scores indicate a better balance.

Sponsors and collaborators

Lead sponsor

Universidad Católica San Antonio de Murcia

Other

Registry information

Official study title

The Effectiveness of Physical Rehabilitation in the Enhancement of Proprioceptive and Cognitive Aspects on Alzheimer Disease Patients

Acronym: GPR

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Nov 6, 2018
Registry last updated
Nov 19, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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