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OpenTrials
Completed

NCT Number: NCT06131970

The Effectiveness of Continuous Ketamine Infusion (KONTINUE)

There are different treatment for chronic pain. One possible treatment is intravenous infusions of ketamine.

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Key information

Conditions

Chronic Pain Fibromyalgia Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Rheumatic Diseases Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Princesse Grace

Monaco, 98000

About this study

Ketamine continuous intravenous infusion for 4 days in Hospital with 0.5 mg/kg/day associated with Magnesium Sulfate 1000mg/day.

Evaluation schedules will be performed at day 15,30 and 60.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pain lasting for more than six months without contraindication to treatment

Exclusion criteria

  • Inability to give consent
  • Severe psychiatric disorder

Treatment and study plan

Primary outcomes

  1. Long-term effectiveness

    Time frame: 1 month

    Improvement of the numerical scale - score 0 to 10 - 10 is the worst

  2. Long-term effectiveness

    Time frame: 1 month

    Clinical Global Impression of Change (CGI-C) - score 1 to 7 - 7 is the worst

Secondary outcomes

  1. Pain relief

    Time frame: 15, 30, 60 days

    Neuropathic Pain Symptom Inventory (NPSI) - score 0 to 10 - 10 is the worst

  2. Variation of quality of life

    Time frame: 15, 30, 60 days

    Short Form 12 health survey

  3. Variation of quality of life

    Time frame: 15, 30, 60 days

    Hospital Anxiety and Depression scale - score 0 to 21 - 21 is the worst

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Princesse Grace

Other

Registry information

Official study title

Effectiveness of Continuous Ketamine Infusion Associated With Magnesium Sulfate for Management of Patient With Chronic Pain : a Prospective Observational Study

Acronym: KONTINUE

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Nov 15, 2023
Registry last updated
Feb 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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