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Completed

NCT Number: NCT01863823

The Effective Treatment of Oral Helicobacter Pylori With the Success Rate of Gastric Eradication

1. Gastric eradication has no effective on oral H. pylori infection. 2. Treatment of oral infection increase success rate of eradication on stomach infection.

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Key information

Conditions

Oral Helicobacter Pylori

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Beijing University First Hospital

Beijiang, 1001, China

About this study

Objective: The present study was aimed to explore the relationship of Helicobacter pylori(H. pylori) of the oral cavity with the success rate eradication of gastric H. pylori infection.

Study Design and Setting: 202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.

We collected data of HPS, HPF , PCR and UBT before treatment on 202 symptomatic patients and 148 asymptomatic individual groups. After drug treatment, we run HPS, HPF, PCR and UBT tests. If the tests of HPS, HPF and PCR show negative that indicate success of oral H.pylori eradication. If the test of UBT show negative that indicate success of stomach H.pyloi eradication. We also compare the suceess rate of eradication on stomach infection with and without oral H. pylori infection.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with gastrointestinal complaints

Exclusion criteria

  • patients who had taken any antibiotics and/or proton pump inhibitors within four weeks prior to sample collection

Treatment and study plan

Amoxicillin and Tetracyclines

Drug

202 symptomatic and 148 asymptomatic individuals were recruited and tested using Saliva H. pylori antigen tests (HPS), H. pylori flagellin (HPF), the urea breathe test (UBT) and the polymerase chain reaction (PCR) test. Test subjects also received various treatments.

Other names: dBest

Mouth washing

Drug

Two time washing mouth per day

Other names: dBest

Primary outcomes

  1. Success Rate

    Time frame: 12 months

Secondary outcomes

  1. Diagnostic

    Time frame: 6 months

Other outcomes

  1. Agreement of diagnostic and success rate of gastric eradication

    Time frame: 12 months

Sponsors and collaborators

Lead sponsor

Ameritek USA

Industry

Registry information

Official study title

Director of Research Division

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
May 29, 2013
Registry last updated
May 29, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.