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OpenTrials
Completed

NCT Number: NCT02013024

The Effect of Vitrification Versus Slow Freezing on Day 3: a Randomised Controlled Trial.

Randomized controlled trial (RCT) testing the hypothesis that vitrification is superior to slow freezing.

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Key information

Conditions

Cryopreservation of Embryos

Age range

18 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Leuven University Fertility Center

Leuven, 3000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients (with female age < 40 years)
  • Patients undergoing a 1st oocyte retrieval for an IVF/Intracytoplasmatic Sperm Injection (ICSI) treatment
  • Patients planned for an embryo transfer on day 3.
  • Patients with supernumerary embryos of sufficient quality for freezing/vitrifying on day 3.
  • Fresh personal (own oocytes)
  • One inclusion in the study per patient.

Exclusion criteria

  • Patients undergoing a 2nd or higher ranked oocyte retrieval after a fresh cycle with failed pregnancy.
  • Female age ≥ 40 year
  • Patients with Preimplantation Genetic Diagnosis (PGD)
  • Patients with donor oocytes
  • Patients with positive serology whose embryos may not be frozen.
  • Patients planned for a transfer on day 2 or day 5.
  • Patients receiving assisted hatching in the embryo transfer in the frozen cycles.
  • Patients who have been included in the study before.

Treatment and study plan

cryopreservation technique

Other

Primary outcomes

  1. Life birth rate per embryo thawed

    Time frame: 3 years

Secondary outcomes

  1. live birth rate per embryo transferred

    Time frame: 3

  2. survival rate

    Time frame: 3 year

  3. implantation rate per embryo transferred

    Time frame: 3 years

  4. implantation rate per embryo thawed

    Time frame: 3 years

  5. abortion rate

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Sophie Debrock

Other

Registry information

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Dec 17, 2013
Registry last updated
Feb 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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