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OpenTrials
Completed

NCT Number: NCT04983394

The Effect of Virtual Reality Exercises on Patients With Post-COVID-19 Condition

This study aims to investigate (I) the effectiveness of motion-controlled video game-based VR exercises on pain, fatigue, functional capacity, mood, and quality of life in patients with PCC, and (II) to determine whether they are superior to conventional exercise.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sivas Cumhuriyet University

Sivas, 58050, Turkey (Türkiye)

About this study

79 individuals aged 18-65 years who were diagnosed with COVID-19 with a PCR test result in an oropharyngeal or nasopharyngeal swab sample taken more than 90 days ago and who had PCC symptoms for at least eight weeks were included. Patients with PCC who had been hospitalized, had signs of pneumonia or organ failure, had suffered an acute myocardial infarction or orthopedic surgery within the last 2 years, had cardiovascular system diseases such as uncontrolled hypertension, arrhythmia, or cardiac insufficiency, had known chronic respiratory system diseases, those with conditions causing widespread pain such as fibromyalgia syndrome, those with primary any neurological system diseases, or those unable to mobilize for any reason were excluded from the study.

The same physiatrist systematically evaluated the sociodemographic data, medical history including the time elapsed since the diagnosis of COVID-19, the duration of PCC symptoms, and outcome measures (fatigue level, pain intensity, general health status, emotional state, functional capacity) through face-to-face interviews at the hospital, and recorded in a standardized form.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed with COVID-19 by polymerase chain reaction from an oropharyngeal or nasopharyngeal swab sample more than 90 days ago, and who had PCC symptoms for at least eight weeks

Exclusion criteria

  • have been hospitalized due to COVID-19,
  • have developed pneumonia or organ failure findings.
  • have had an acute myocardial infarction in the last 2 years,
  • have cardiovascular system disease such as uncontrolled hypertension, arrhythmia, aneurysm, cardiac failure,
  • have undergone fracture or orthopedic surgery in the last 2 years,
  • have a known chronic respiratory system disease,
  • have widespread pain such as fibromyalgia syndrome

Treatment and study plan

Virtual Realty Exercises

Other

motion-controlled video game

conventional exercises

Other

aerobic, strength, stretching, and neuromuscular exercises

Primary outcomes

  1. visual Analogue Scale

    Time frame: 8th week

Secondary outcomes

  1. hospital anxiety and depression scale-Depression

    Time frame: 0th and 8th week

  2. hospital anxiety and depression scale-Anxiety

    Time frame: 0th and 8th week

  3. Fatigue severity scale

    Time frame: 0th and 8th week

  4. Short Form-12

    Time frame: 0th and 8th week

  5. 6 minutes walking test

    Time frame: 0th and 8th week

Sponsors and collaborators

Lead sponsor

Cumhuriyet University

Other

Registry information

Official study title

Effect of Motion-Controlled Video Games-Based Virtual Reality Exercise On Pain, Fatigue, Mood, Functional Capacity, And Quality of Life in Patients With Post-Covid-19 Condition: A Randomized Controlled Trial

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jul 30, 2021
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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