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Completed

NCT Number: NCT02520999

The Effect of Various External Pressure on Blood

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used. The investigators will study correlation between external pressure and hemolysis and deformability of red blood cell.

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Key information

Conditions

Hemorrhage Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

20 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Korea university anam hospital

Seoul, 136705, South Korea

About this study

Rapid infusion of blood is needed occasionally for control massive bleeding. For rapid infusion, external pressure can be used which cause hemolysis and alteration of red blood cell. The investigators will study correlation between variable external pressure and hemolysis and deformability of red blood cell. Differ from previous study, the investigator will use scanning electron microscope for observation red blood cell.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers, without any underlying disease.

Exclusion criteria

  • history of delivery, abortion in past 6 months.
  • weight : male under 50kg, female under 45kg
  • heart rate under 50 or over 100
  • fever : over 37.5
  • blood pressure : over 180/100

Treatment and study plan

Auto PC(Acemedical, Goyang-si, Korea) - 0mmHg(control)

Device

Blood pass through infusion set without external pressure.

Auto PC(Acemedical, Goyang-si, Korea) - 150mmHg

Device

Blood pass through infusion set under external pressure (150mmHg)

Auto PC(Acemedical, Goyang-si, Korea) - 200mmHg

Device

Blood pass through infusion set under external pressure (200mmHg)

Auto PC(Acemedical, Goyang-si, Korea) - 250mmHg

Device

Blood pass through infusion set under external pressure (250mmHg)

Auto PC(Acemedical, Goyang-si, Korea) - 300mmHg

Device

Blood pass through infusion set under external pressure (300mmHg)

Primary outcomes

  1. Hemolysis and alteration of deformability of red blood cell caused by external pressure

    Time frame: 1hour

Sponsors and collaborators

Lead sponsor

Hyub Huh

Other

Registry information

Official study title

Comparison of the Effect of Various External Pressure on Blood During Rapid Infusion

Acronym: EPB

Important dates

Study start
2015
Primary completion
2015
Study completion
2015
First posted
Aug 13, 2015
Registry last updated
Nov 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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