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Completed

NCT Number: NCT02009475

The Effect of Two Exercise Training Protocols on Physiological and Biochemical Parameters in Congestive Heart Failure

The aim of the present study is to evaluate differential lactate removal kinetics in heart failure patients that are trained according to 2 different exercise protocols:

(A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT)

Completed

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sheba Medical Center, Cardiac Rehabilitation Institute

Tel Hashomer , Ramat Gan, Israel

About this study

Introduction: Congestive heart failure (CHF) patients suffer from early fatigue and functional aerobic impairment. Their reduced cardiac output and O2 delivery to the peripheral muscles shifts those patients consistent anaerobic metabolism, thus, CHF patients rely on anaerobic metabolism even in everyday life activity. This metabolism leads to a shift of muscles fiber types from mainly slow twitch, oxidative type I fibers to fast twitch, glycolytic type IIb fibers. Monocarboxylate proteins MCT1 and MCT4 transport lactate crosses the membrane. MCT1 is responsible for the lactate uptake and MCT4 is responsible for efflux of excess lactate. Exercise training is known to improve the quality of life in CHF. We hypothesized that exercise training might change MCT1 and 4 expression and distribution. Accordingly, these changes may also affect lactate clearance during recovery, which may contribute to the beneficial effect of exercise training in CHF patients. Methods: New-York Heart association (NYHA) class II-III CHF patients will be assigned to the experiment. At baseline and upon training conclusion they will undergo the same tests battery. The test battery includes heart rate, blood pressure measurements, echocardiographic evaluation. All participants will fill out "Minnesota living with heart failure" questionnaire. Subsequently, after their basal blood lactate will be assessed they will undergo measurement which will be followed by lactate clearance-rate evaluation.

Randomly each patient will then be assigned to one of two experimental training groups: (A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT). Each volunteer will be trained twice a week for 12 weeks, according to his/hers assigned training protocol and in accordance to exercise training guidelines.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Stable heart failure patients referred to exercise training in a tertiary care cardiac rehabilitation institute
  • Age > 21

Exclusion criteria

  • Severe symptomatic heart failure
  • Severe orthopedic limitations
  • Unstable arrythmia
  • Cognitive decline or substance abuse
  • Unable to comply with exercise protocol
  • Significant pulmonary disease
  • NYHA 4 heart failure class

Treatment and study plan

Interval exercise training

Other

Continues aerobic training

Other

Primary outcomes

  1. Lactate clearance kinetics

    Time frame: Baseline and following 12 weeks of training

    Change from baseline of lactate clearance kinetics followoing a 12 weeks exercise program based on two different training protocol (continues and interval training)

Secondary outcomes

  1. Peak VO2 change

    Time frame: Pre- and post 12 week exercise program

    Change from baseline of the peak VO2 following the 12 weeks exercise program

Other outcomes

  1. Quality of life questioner (MLWHF)

    Time frame: Pre training and 12 weeks later post exercise training period

Sponsors and collaborators

Lead sponsor

Dr. Robert Klempfner Heart Rehabilitation Institute

Other Gov

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Dec 12, 2013
Registry last updated
Oct 25, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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