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Completed

NCT Number: NCT04233177

The Effect of Trendelenburg Position on CCA Blood Flow

The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.

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Key information

Conditions

Perfusion Digestive System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Perioperative/Postoperative Complications Peritoneal Diseases Pneumoperitoneum Postoperative Complications

Age range

20 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Jin-Tae Kim

Seoul, South Korea

About this study

The study will include 20 patients undergoing gynecological surgery. The common carotid artery blood flow will be measured using Doppler US during the following conditions; supine position before induction of anesthesia, supine position immediately after induction of anesthesia, supine position with penumoperitoneum, head-down position with or without pneumoperitoneum.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA class I,II
  • patients undergoing gynecology surgery under trendelenburg position
  • Age ranges from 20 to 70

Exclusion criteria

  • BMI > 32
  • Pregnancy
  • Patients who did not agree to study
  • Patients with allergies to the drugs used in this study
  • Patients with anatomical variations or lesions in cervical or cranial vascular portion
  • Patients with arrhythmia that may alter patient's cardiac output(e.g. artrial fibrillation)

Treatment and study plan

Primary outcomes

  1. Change of the common carotid artery blood flow velocity

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Common carotid artery blood flow velocity is measured using Doppler US

Secondary outcomes

  1. Change of the common carotid artery beat volume

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Common carotid artery beat volume was calculated from median common carotid artery beat velocity and vessel diameter

  2. Change of the common carotid artery diameter

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Common carotid artery diameter is obtained using US

  3. Change of mean arterial blood pressure

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Mean arterial pressure is obtained concurrently with common carotid artery blood flow velocity measurements

  4. Change of cardiac output

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Cardiac output was obtained using FloTrac(EdwardLifescience, USA)

  5. Change of peak inspiration airway pressure

    Time frame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position

    Peak inspiratory airway pressure is obtained using the ventilator system

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

Influence of Anesthesia, Pneumoperitoneum, and Patient Position on Common Carotid Artery Blood Flow During Laparoscopic Gynecology Operation

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jan 18, 2020
Registry last updated
Jan 19, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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