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Completed

NCT Number: NCT04134195

The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions

Recently, attention has been drawn to non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS), in order to enhance cognitive functions by modifying brain plasticity and use it in different healthy and diseased populations. In the current research, investigator aim to examine the short-term effects of multiple tDCS protocols in healthy adults population on visual attention and identify the neural underpinnings of tDCS-induced behavioral aftereffects using a combined tDCS/ MRI network-based approach.

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Key information

Conditions

Healthy Aging Cognition Disorders Cognitive Change Cognitive Decline Cognitive Dysfunction Mental Disorders Neurocognitive Disorders

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ceitec, Masaryk University

Brno, 61300, Czechia

About this study

Investigator will investigate the shor-term effects of active tDCS as compared to a placebo stimulation on visual attention in the healthy seniors. A cross-over, randomized, placebo-controlled design will be used. Single tDCS sessions will be performed in 4 sessions over distinct brain areas with ongoing visual attention training. During the stimulation, investigator will use the visual matching task. MRI protocol consisting of T1 and resting state fMRI sequences will be acquired before and after every stimulation session in order to search for active vs. placebo tDCS-induced changes in brain activation and resting state functional connectivity and to identify neural correlates of behavioral changes.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right handed, healthy volunteers in two groups - healthy adults under 40 years, healthy seniors over 50 years

Exclusion criteria

  • psychiatric disorders, including major depression, major vascular lesions, and other brain pathologies detected by MRI that might present with cognitive decline
  • a cardio pacemaker or any MRI-incompatible metal in the body
  • epilepsy
  • any diagnosed psychiatric disorder
  • alcohol/drug abuse
  • lack of cooperation
  • presence of cognitive impairment

Treatment and study plan

Transcranial Direct Current Stimulation

Device

2mA stimulation for 20 minutes

Primary outcomes

  1. Visual-attention task accuracy

    Time frame: Change from baseline immediately after completion of stimulation protocol

    Task will be presented on a computer and subject will respond by YES-NO buttons. Only if there are no differences in task accuracy, we will measure task reaction times (e.g. due to the roof effect).

  2. Magnetic resonance imaging

    Time frame: Change from baseline immediately after completion of stimulation protocol

    Investigator will record high resolution structural T1-weighted (MPRAGE) images, functional T2* weighted multiband EPI sequences. The total time spent in the scanner will be approximately 40 in every session.

Sponsors and collaborators

Lead sponsor

Masaryk University

Other

Collaborators

  • St. Anne's University Hospital Brno, Czech Republic

Registry information

Official study title

The Effect of Transcranial Direct Current Stimulation on Visual Attention - a Combined MRI and Non-invasive Brain Stimulation Single Session Study

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Oct 22, 2019
Registry last updated
Feb 24, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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