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Completed

NCT Number: NCT06255821

The Effect of Time on Generalization of Exposure-based Benefit

Participants will receive a pre-assessment and an exposure with a control spider. This control spider will be presented again at post-training assessments. Participants will then be assigned to one of the follow-up assessments: one week, six weeks or three months. The control spider (spider A) and a novel spider (spider B) will be used again at follow-up BATs to test for generalization of exposure effects.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Behavioral and Clinical Neuroscience

Bochum, 44787, Germany

About this study

Several findings from basic research on extinction learning undermine the role of time effects in the contextualization and retrieval of extinguished memories (Archbold et al., 2013; Quirk, 2002; Wiltgen & Silva, 2007). The latter bears important implications for the evaluation of short- and long-term effects of exposure-based fear reduction and generalization. To date, no study exists examining the role of time on the fear responding to treated stimuli and/or untreated stimuli after successful exposure. It will be investigated whether the differential responding to treated and untreated stimuli after exposure is dependent on the passage of time.

Spider fearful participants will be subjected to a standardized one-session treatment with spiders serving as treatment stimuli. Fear reduction towards treatment stimuli will be assessed at post-treatment. Furthermore, generalization of exposure therapy towards untreated stimuli (i.e., a novel spider) will be assessed. The extent of generalization of exposure-based fear reduction to untreated stimuli will be compared between three groups that will differ with respect to the follow-up length. Here, participants undergoing exposure will be randomly assigned to one of the following follow-up measurements: one week follow-up, six weeks follow-up, and three months follow-up. The extent of exposure induced fear reduction and generalization will be assessed and compared between these groups.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Presence of fear of spiders (Potential diagnosis of arachnophobia)

Exclusion criteria

  • Reaching level 10 or higher in the initial (Pre-Exposure) Spider BAT
  • Any acute or chronic mental and / or somatic disease
  • Psychological, psychiatric, neurological or pharmacological treatment
  • Drug or alcohol abuse
  • Pregnancy

Treatment and study plan

Exposure

Behavioral

One-session of graded in-vivo exposure with a spider. Each task is first modeled by the experimenter. Prior to the exposure, participants receive psychoeducation on anxiety and phobias.

Primary outcomes

  1. Behavioral Approach Test (BAT)

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in the Behavioral Approach Test (BAT) at post-assessment and follow-up with the control spider (spider A; treated stimulus) and a novel spider (spider B; untreated fear stimulus). During the Behavioral Approach Test (BAT) the closest distance to a spider is measured.

  2. Subjective fear

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in subjective fear at post-assessment and follow-up with the control spider (spider A; treated stimulus) and a novel spider (spider B; untreated fear stimulus) is measured during the Behavioral Approach Tests.

  3. Subjective disgust

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in subjective disgust at post-assessment and follow-up with the control spider (spider A; treated stimulus) and a novel spider (spider B; untreated fear stimulus) is measured during the Behavioral Approach Tests.

  4. Heart rate

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in heart rate at post-assessment and follow-up with the control spider (spider A; treated stimulus) and a novel spider (spider B; untreated fear stimulus) is measured during the Behavioral Approach Tests.

Secondary outcomes

  1. Score on General Self-efficacy (GSE) Scale

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in self-efficacy is measured by the GSE Scale. The GSE Scale contains ten items and measures how confident the person feels to overcome difficult situations based on their self-assessed competence. The total score is determined by summing up all item scores, which results in a score between 10 and 40, where the higher scores represent higher GSE.

  2. Self-efficacy Questionnaire for Phobic Situations (SEQ-SP)

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    The questionnaire consists of 13 items. The items describe specific phobic situations (in relation to animals) for which the participants has to assess their self-efficacy expectations based on a five-point scale (1 = really sure I couldn't, 5 = really sure I could).

  3. Fear of Spiders Questionnaire (FSQ)

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    Change in the Spider-fear related questionnaires. The Fear of Spiders Questionnaire (FSQ) will be applied. Scores on this scale range from 0 to 108, with higher scores indicating greater fear of spiders.

  4. Spider Fear Questionnaire (SPQ)

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    The Spider Fear Questionnaire (SPQ) will be applied. Scores on this scale range from 0 to 31, with higher scores indicating greater fear of spiders.

  5. Spider Beliefs Questionnaire (SBQ)

    Time frame: Pre-assessment (immediately before exposure), post-assessment (one day after exposure), follow-up (one week, six weeks, or three months after exposure)

    The Spider Beliefs Questionnaire (SBQ) will be applied. Scores on this scale range from 0 to 100, with higher scores indicating greater fear of spiders.

Sponsors and collaborators

Lead sponsor

Ruhr University of Bochum

Other

Registry information

Official study title

The Effect of Time on Generalization of Exposure-based Benefit in Spider Fear

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Feb 13, 2024
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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