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Completed

NCT Number: NCT05391620

The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.

3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of ~ 70% of one repetition maximal (1RM).

Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.

The investigators collect blood sample before exercice, after HIIT and after RT.

It is randomized cross-over study.

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Key information

Conditions

Heart Failure Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Myocardial Ischemia Resistance Training Vascular Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Erasme Hospital

Brussels, 1070, Belgium

About this study

The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.

The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical Coronary artery diseases
  • Heart failure with reduced ejection fraction

Exclusion criteria

  • angina
  • acutely decompensated heart failure
  • electrocardiographic evidence of ischemia
  • significant valvular disease
  • orthopedic/neurologic disorders that limited exercise

Treatment and study plan

Cardiac rehabilitation with 3/7 method

Other

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension.

1 minute between each machine is planned.

Other names: 3/7 method

Cardiac rehabilitation with 3X9 method

Other

HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension.

1 minute between each machine is planned

Other names: 3X9 method

Primary outcomes

  1. Change in Lactate

    Time frame: within 2 minutes after TR training session on day 1

    mmol/l

  2. change in Testosterone

    Time frame: within 2 minutes after TR training session on day 1

    nmol/l

  3. change Glucocorticoid Cortisol

    Time frame: within 2 minutes after TR training session on day 1

    nmol/l

  4. change in Growth Hormone

    Time frame: within 2 minutes after TR training session on day 1

    ng/ml

  5. change in ph

    Time frame: within 2 minutes after TR training session on day 1

    venoust

  6. change PCO2 venoust

    Time frame: within 2 minutes after TR training session on day 1

    mm Hg

Secondary outcomes

  1. Borg scale

    Time frame: within 4 minutes after TR training session on day 1

    Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion)

  2. Pleasure of the session scale

    Time frame: within 4 minutes after TR training session on day 1

    0 = worse 10 = better

Sponsors and collaborators

Lead sponsor

Université Libre de Bruxelles

Other

Registry information

Official study title

Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
May 26, 2022
Registry last updated
Feb 14, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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