The Effect of Sugar Load in IBS Patients Depending on Sucrase-isomaltase Genes

The investigators know that many patients with irritable bowel syndrome (IBS) have functional variants of genes coding for sucrase-isomaltase enzymes. The investigators will now examine whether these functional variants are associated with defect degradation of sucrose and associated gastrointestinal symptoms

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Key information

Conditions

Sucrase-Isomaltase Deficiency Colonic Diseases Colonic Diseases, Functional Digestive System Diseases Gastrointestinal Diseases Intestinal Diseases Irritable Bowel Syndrome Sucrase-isomaltase deficiency, congenital

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Internal Medicine, Skåne University Hospital

Malmö, 20502, Sweden

About this study

The investigators have in a previous study included IBS patients for treatment with a starch- and sucrose reduced diet (SSRD). The investigators found a great improvement of symptoms. The investigators gene-tested those patients, and now have the full identification of all functional variants encoding sucrase-isomaltase enzymes.

The investigators will invite patients from this previous study with normal genes and functional variants of genes. The patients will come fasting over night to the department of clinical research. The participants will ingest 75 g sugar dissolved in 0.8 dl water and flavored with lemon, to ingest during 5 minutes. After that, glucose will determined repeatedly up to 2 hours afterwards. At the same time, the participants have to assess their gastrointestinal sympotms on visual analogue scales (VAS).

The investigators will compare the raise in b-glucose and symptoms between the groups of patients, divided into gene expression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Participants of our previous clinical trial with SSRD diet (NCT03306381)

Exclusion criteria

Difficulties in taking blood samples

Treatment and study plan

Sugar

Dietary Supplement

75 g sugar dissolved in 0.8 dl water and flavored with lemon. Ingested during 5 minutes

Primary outcomes

Changes from baseline of blood glucose levels

Time frame: From distribution repeatedly up to 2 hours

Measurement of glucose levels in blood drawn from an intravenous needle and analyzed at the Department of Clinical Chemostry
Change from baseline of gastrointestinal symptoms

Time frame: From baseline and up to 2 hours, at the same time points as blood glucose is measured

Measurment of gastrointestinal symptoms on a visual analog scale measuring symptoms, range 0-100 mm, repeatedly at the same time points as blood glucose is measured. The higher scores, the worse symptoms.

Sponsors and collaborators

Lead sponsor

Region Skane

Other

Registry information

Official study title

Comparison of Sugar Load Between Normal and Functional Variants of Sucrase-isomaltase Genes in IBS

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2025
First posted: Jan 18, 2023
Registry last updated: Jun 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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