The Effect of Stevia Rebaudiana Extracts on Different Variables Related to Caries: an in Vitro and in Vivo Evaluation.

The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.

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Key information

Conditions

Dental Caries Stomatognathic Diseases Tooth Demineralization Tooth Diseases

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

good general health, normal salivary secretion rate, normal buffer capacity

Exclusion criteria

systemic diseases, salivary secretion reduction, reduced buffer capacity

Treatment and study plan

Effect of Stevioside and Rebaudioside on plaque pH

Dietary Supplement

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Primary outcomes

Plaque-pH modification

Time frame: 5, 10, 15, 30, 45, 60 minutes

Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse

Sponsors and collaborators

Lead sponsor

Università degli Studi di Sassari

Other

Collaborators

University of Milan

Registry information

Official study title

A Comparative Clinical Evaluation of the Effect of Stevia Rebaudiana Extracts and Sucrose on Dental Plaque pH (Stephan Curve Trend) Using a Microtouch Electrode in Healthy Volunteers. A Phase II Study.

Important dates

Study start: 2012
Primary completion: 2012
Study completion: 2012
First posted: Dec 31, 2012
Registry last updated: Jan 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed